cvs pharm (DONT USE)

Question 1

non-selective beta blockers

Answer 1

• propranolol
• pindolol
• carvedilol

Question 2

which non-selective beta blocker is approved to treat heart failure

Answer 2

carvedilol

Question 3

which cardioselective (B1) beta blockers are approved to treat heart failure

Answer 3

• bisoprolol
• metoprolol XL (succinate)

Question 4

cardioselective (B1) beta blockers

Answer 4

• atenolol
• bisoprolol
• metoprolol XL (succinate)

Question 5

what does it mean by mixed (or 3rd gen) beta blocker

Answer 5

has diff selectivities at diff doses

Question 6

Mixed (or 3rd gen) beta blocker

Answer 6

Nebivolol

selective in low dose, non-selective in high dose
approved to treat heart failure

Question 7

clinical use of Isosorbide Dinitrate (ISDN) and ISMN

Answer 7

angina prophylaxis

Question 8

PD features of nitrates

MOA @ diff doses

Answer 8

• low plasma conc:
  venous dilation
  -> peripheral pooling of blood
  -> decreased venous return
  -> lower preload
  
  • high plasma conc:
    dilation of arteries
    -> decreased systemic vascular resistance
    -> lower afterload

Question 9

adverse effects of ivabradine

Answer 9

• visual problems: luminous phenomena, transient enhanced brightness
• ## bradycardia associated symptoms (e.g. dizziness)