CVS/Cardio Flashcards
Most efficient extractor of oxygen from the blood
Heart
Intracellular junctions responsible for the cardiac syncytium
Gap junctions
Substance that dilates upstream blood vessels
Endothelium-derived relaxing factor (EDRF) aka Nitric oxide (NO)
Most potent vasoconstrictor
ADH (can increase levels of Endothelin-1)
An increase in venous return will increase the heart rate
Brainbridge reflex
An increase in venous return will increase the stroke volume.
Basis: stretching if cardiac sarcomeres will increase contraction
Frank-starling mechanism
Hypertension
Irregular respiration
Bradycardia
Due to activation of the CNS ischemic response and baroreceptor reflex in increased ICP
Cushing reflex
Formula for Blood pressure based ob Ohm’s Law
BP= CO x TPR CO= HR x SV
TPR is synonymous with SVR and increases when arterioles vasoconstricted
Normal pressures at various parts of adult circulation
Large arteries: <120/80 mmHg Sytemic capillaries: 17 mmHg Vena cava : 0 mmHg Pulmonary artery : 25/8 mmHg Pulmonary capillaries : 7 mmHg
At least 10 second pressure over the RUQ
+ response: sustained rise of >3 cm in JVP for at least 10-15 sec after release of the hand
Abdominojugular reflux
Pansystolic murmur of tricuspid regurgitation
Louder during inspiration and diminishes during forced expiration
Carvallo’s sign
Apical pulse is reduced and may retract in systole in CONSTRICTIVE PERICARDITIS
Broadbent’s Sign
High pitched, diastolic, decresendo blowing murmur along the left sternal border due to dilation of the pulmonary valve ring
- occurs in Mitral Valve disease and severe Pulmonary Hypertension
Graham Steell Murmur
Condition where the murmur of Aortic Stenosis may be transmitted downward and to the apex and may be confused with the sytolic murmur of Mitral Regurgitation
Gallavardin Effect
Peripheral Signs of AORTIC REGURGITATION
- ) CORRIGAN’S PULSE: rapidly rising “WATER HAMMER” pulse that collapses suddenly as arterial pressure falls rapidly during late systole and diastole
- ) QUINCKE’S PULSE: capillary pulsations , alternate flushing and paling of the skin while pressure is applied to the tip of the nail
- ) TRAUBE’S SIGN: booming “PISTOL SHOT” sound heard over the femoral arteries
- ) DUROZIEZ SIGN: to-and-from murmur audible if the femoral artery is lightly compressed with steth
Most noninavsive marker of increased CV morbidity/mortality risk
LVH (Left Ventricular Hypertrophy)
Cornerstone in the diagnosis of acute and chronic heart disease
ECG
Ideal imaging modality for cardiac emergencies
2D-ECHO
Gold standard for imaging valve morphology and motion,detection of pericardial effusion and cardiac tamponade, and assessment of LV cavity size, systolic function and wall thickness
2D- ECHO
Gold standard for assessing LV mass and volumes
MRI
Imaging modalities of choice for the evaluation of suspected aortic aneurysm or aortic dissection and in distinguishing between restrictive and constrictive pericarditis
CT scan and MRI
Gold standard in assessing the anatomy & physiology of the heart & associated vasculature
Cardiac catheterization and coronary angiography
Triad of RUPTURED ANEURYSM
- ) Left flank pain
- ) Hypotension
- ) Pulsatile mass
Diagnostic triad of Wolff-Parkinson-White (WPW) ECG Pattern
- ) Wide QRS complex
- ) Relatively short PR interval
- ) Slurring of the initial part of QRS complex ( delta wave)