CVS Flashcards
What are the three linings of the heart?
Endocardium, myocardium, and epicardium
What is the deoxygenated blood flow route?
In through the superior/inferior vena cava, right atrium, tricuspid valves, right ventricle, semilunar valve, out through the pulmonary artery to be oxygenated
What is the oxygenated blood flow route?
In through the pulmonary vein, the right atria, bicuspid valve, right ventricle, aortic valve, out the aorta
What is the route of conduction in the heart?
SA node -> AV node -> crosses to the bundle of His -> down through purkinje fibers
Normal rhythm of the heart can also be called?
Sinus rhythm
What does the P wave signify on an ECG?
SA node is firing and depolarization of the atria (contraction)
What does the QRS complex signify on an ECG?
AV node electrical pulse and depolarization of the ventricles (contraction)
At what phase of an ECG does atrial repolarization happen?
QRS complex
What does the T wave signify in an ECG?
Repolarization of the ventricles
What do the intervals between ECG segments/waves indicate?
They indicate how long it takes for the conduction to travel from one area of the heart to another
What six factors effect cardiac output?
HR, SV, preload, afterload, atrial kick, and cardiac reserve
Define SV
Amount of blood ejected by the left ventricle during each systolic contraction
What effects SV?
affected by preload, contractility, and afterload
Define CO
amount of blood pumped by the ventricles in one minute
Define preload
The volume of blood in the ventricles at the end of diastole, before the next contraction
In addition, the amount of stretch placed on the myocardial fibres
The amount of stretch on myocardial fibres may also be classified as?
Preload
Describe Starling’s law
The more fibers are stretched (i.e., the greater the preload), the greater is their force of contraction/contractility and recoil, within a physiological range
Often in HF, the heart becomes overstretched and cannot recoil. This causes risk of?
Blood pooling and clotting
What is one way to increase preload? One way to decrease it?
A fluid bolus would increase preload and diuretics will decrease it due to reduced blood volume
Define afterload
The peripheral resistance that the left ventricle must pump against (ventricle size, wall tension, and arterial BP)
Are enlarged or smaller ventricles more effective for contractility?
Enlarged ventricles are ineffective to contractility, we want smaller ventricles
Define atrial kick
Occurs in the final phase of atrial systole, where the atria contract and eject a bolus of blood into the ventricles
Define cardiac reserve
The CVS may increase its workload/rate by 3-4x to meet demand during heightened/high epinephrine situations
Is the cardiac reserve a sustainable source over time?
No
Define/briefly describe arteries, arterioles, capillaries, veins, and venules
Arteries – thicker, elastic, larger ones have smooth muscle
Arterioles – little elastic tissue and more smooth muscle
Capillaries – thin, endothelial cells, no elastic or muscle tissues
Veins – large diameter, thin walled, larger ones have semi-lunar valves
Venules – small, small amount of muscle and connective tissue
What are the two locations of baroreceptors?
The aortic arch and carotid sinus
What are baroreceptors sensitive to and where do they transmit their feedback?
They are sensitive to stretch and pressure and they send their feedback to the brainstem
An increase in CO will ___ (stretch/constrict) the periphery and create a ___ (decrease/increase) in HR due to an (increase/decrease) in blood volume
Stretch, decrease, increase
Where are chemoreceptors located?
aortic arch and carotid bodies
What are chemoreceptors sensitive to?
They create responses based on hypoxia (decreased arterial oxygen), hypercapnia (increased arterial CO2), and acidosis (decreased plasma pH)
What is the formula for BP?
BP = CO x SVR (systemic vascular resistance)
What is the formula for pulse pressure?
SBP - DBP
What do the following diagnostic/blood studies indicate? CBC, troponin, creatine kinase
CBC - complete blood; indicates counts of WBC, RBC, and platelets
Troponin - measurements of contractile proteins (released after an MI)
Creatine kinase (CK) - measurement of enzyme found in skeletal and heart muscle, and the brain (indicates muscle injury or death)
What do the following diagnostic/blood studies indicate? Serum creatinine, BUN, CRP
Serum creatinine - indicates waste product of protein breakdown, approximates GFR
BUN - measurement of nitrogen in the blood from waste product of urea
CRP - measurement of a marker of inflammation
What blood study can be predictive of the risk of cardiac disease, inflammation, and cardiac events?
CRP
What do the following diagnostic/blood studies indicate? BNP, triglycerides, cholesterol, HDL, LDL
BNP - measurement of a peptide that causes natriuresis (sodium in the urine)
Triglycerides - measurement of mixture of fatty acids
Chol - measurement of blood lipid
HDL - measurement of a form of cholesterol that helps remove other forms
LDL - measurement of the form of the bodies of major cholesterol
What diagnostic/blood study indicates the presence of HF and may help distinguish cardiac vs respirator related dyspnea?
BNP
BNP is released when the ___ swell?
Ventricles
What is Holter monitoring?
recording of an ECG rhythm over a 24-48 hour period
What is a cardiac stress test?
Studies the effect of exercise tolerance on the CVS
What is cardiac angiography?
Procedure that assesses the coronary circulation
How do baroreceptors respond to an increased blood pressure?
Respond to stretch due to increased BP and blood volume, send an inhibitory impulse to the brainstem which results in decreased HR, force of contraction, and vasodilation
How do baroreceptors respond/adjust to continuous hypertension?
Baroreceptors adjust to the higher rates of BP and recognize these levels as normal
What is the vascular endothelium? What can happen to it to cause issues with BP?
A single cell layer that lines the blood vessels
It can be potentially narrowed from deposits of lipids and cholesterol
How does the body compensate for deposits of lipids and cholesterol lining the vascular endothelium?
The body will add fibrin around the deposits to try and wall them off
How does the RAAS system affect blood pressure?
It determines whether to conserve or excrete water, which will modify the blood volume - an increase of sodium will increase water intake
What enzyme do the kidneys release when they require greater amounts of fluid and blood?
Renin
What three hormones are released by the endocrine system to increase BP?
ADH - increased of ADH increase ECF, which in turn increases blood vol. and BP
Epinephrine - increases CO, HR, and myocardial contraction
Aldosterone - stimulates the kidneys to retain sodium and water, which increases BP and CO