CVR

Question 1

Mean SNS response is?

Answer 1

systemic

Question 2

M2, ⍺2, D2 all activate what?

Are presynap or postsynap?

Answer 2

Gi (inhib adeny cyclase - decrease cAMP)

presynaptic

Question 3

In presynaptic regulation, what receptor/mediator combos ↑ neurotrans release?

Answer 3

β2 / A
AT1 / AngII

*All others are inhibitory

Question 4

In presynaptic regulation, what INHIBITORY receptor/mediator combo is pharmacologically important?

Answer 4

⍺2 / NE/E

Question 5

Postsynaptic regulation of neurotrans achieved how? (2)

Answer 5

1) up or down reg of receptors

2) desensitization of receptors

Question 6

Autonomic Feedback Loop responds to what?

Answer 6

Δ in MAP thru baroreceptors

Question 7

Auto feedback loop process?

Answer 7

↓ MAP ->
fast baroreceptors stim vasomotor center ->
Activates SNS, Deactivates PNS

Question 8

Activated SNS in response to ↓ BP causes?

Answer 8

↑ venous tone (↑venous return),
↑ contractile force (↑ stroke vol),
↑ HR (↑ CO),
↑ peripheral vascular resistance

Results in ↑ MAP

Question 9

Deactivation of PNS in response to ↓ BP causes?

Answer 9

↓ in HR inhibition

Question 10

Hormonal Feedback Loop responds to what?

Answer 10

blood flow to kidney (blood volume)

Question 11

Hormonal feedback loop process?

Answer 11

Extended ↓ MAP -> ↓ BF to kidney ->
↑ Renin -> ↑ Ang -> ↑ aldosterone ->
↑ Na+/H2O retention ->
↑ blood vol