CVD Flashcards
DESCRIBE THE PROCESS IN THIS INFARCTED TISSUE
A. Ischemic tissue stains faintly with eosin, is vacuolated and spongy.
B. Ischemic (red) neurons display a strongly eosinophilic, shrunken perikaryon and a homogenous dark basophilic nucleus (HE).
C. Myelin disintegrates into small lipid globules (LFB-CV) and
(D) the axons into small fragments (Holmes stain). E. Capillaries are prominent (reticulin stain).
WHAT FILLS THE PERIVASCULAR TISSUE
Histologic evolution of infarcts. Vasogenic edema. A. Plasma fl uid fi lls the perivascular space
WHAT INVADES THE TISSUE
Polymorphonuclear
leukocytes invade the ischemic tissue during
the fi rst 24 hours (HE).
WHAT TYPE OF CELLS ARE SHOWN
Histologic evolution of infarcts.
Macrophage activation.
A. By the second and third day, macrophages invade the necrotic tissue.
B. Cytoplasms of macrophages are fi lled with tissue debris, which is then removed to the perivascular spaces. C. Collection of
macrophages around a blood vessel
WHAT CELLS ARE SHOWN
Histologic evolution of infarcts.
Marginal astrocytic proliferation.
A. Chronic cavitated infarct contains a few
remaining capillaries and macrophages
within the lumen.
B. The margin consists
of proliferated gemistocytic astrocytes
(HE).
THIS PT HAS PAN, DESCRIBE THE VESSEL
A nutrient artery of the sciatic
nerve shows acute fi brinoid necrosis with polymorphonuclear
and monocytic leukocytes
WHAT DISEASE CAUSING STROKE?
Thromboangiitis obliterans in a 50- year-old man. A. Leptomeningeal artery shows marked intimal proliferation
and thrombotic occlusion.
B. The cortex shows multiple small cystic
infarctions (HE).
THIS PT PRESENTED WITH STROKE. DESCRIBE THE DEPOSITS
Amyloid angiopathy.
A. Amyloid angiopathy
associated with lobar centroparietal
hemorrhage in a 72-year-old man.
B. Amyloid deposits in walls of small
blood vessels (Congo red).
DESCRIBE THE ARTERY SHOWN
Dolichoectasia in an 83-year-old man.
A. The basilar artery is tortuous, its wall is thin and soft, and the lumen distended. The artery is the continuation
of the thin-walled right vertebral artery.
B. The wall of the basilar artery is fi brotic, the elastic lamina is fragmented and partially missing (Verhoeff
elastic stain).
DESCRIBE THE DEPOSITS SHOWN
Siderocalcinosis of blood vessels in globus pallidus. Basophilic mineral deposits
A. in the intima and media (HE),
B. in full thickness of the wall, partially obliterating the lumen (Gomori iron stain) and,
C. destroying the vessel’s wall (Von Kossa calcium
stain). D. CT scan showing mineralization in globus pallidus.
WHAT IS SHOWN IN THIS PT PRESENTING WITH SUDDEN NECK PAIN
Arterial dissection. Nontraumatic massive mural hematoma
in a carotid endarterectomy specimen
A. Fibrohyalinosis and mural thickening of a small blood vessel in the white matter (HE).
B. Diffuse and multifocal ischemic demyelination
WHAT DISEASE
BINSWANGER
A. Gross appearance in the occipital lobe. Cortex from different cases shows
(B) small vascular cavity (HE) and
(C) subpial and pericapillary glial scars (Holzer stain).
WHAT DISEASE
GRANULAR CORTIICAL ATROPHY
A. Severely dilated, round perivascular spaces in the basal ganglia and slit-like cavities in the subinsular white
matter.
B and C. The dilated perivascular spaces are fi lled with fi ne collagenous fi brillary strands. Occasional hemosiderin pigments
are noted (LFB-CV-E).
WHAT STATE?
Cribriform state.
