CV1-PharmChart Flashcards
what are the 2 drugs that are vasodilator: Nitrates
Isosorbide Dinitrate
Nitroglycerin
MOA of Isosorbide Dinitrate
Smooth muscle dilation of arteries and veins
Class of Isosorbide Dinitrate
Vasodilator: Nitrates
Indication of Isosorbide Dinitrate
frequent stable angina
SE with Isosorbide Dinitrate
Headache, hypotension, tachycardia, re-bound HTN
Common Dx-Dx interaction of ALL vasodilators: Nitrates
PDE-5 inhibitors
What is important to remember time wise about Isosorbide Dinitrate
want a 6-12 hour of nitrate free interval DAILY!
Drug class of Nitroglycerin
Vasodilator: Nitrates
MOA of Nitroglycerin
Smooth muscle dilation of the arteries and veins
Indications of Nitroglycerin
Angina, CHF
What forms does Nitroglycerin come in
and what are the two most important SE:
SL spray
SL or buccal tablet
topical
IV
SE: headache, dizzyness
What is it important to remember about storage of Nitroglycerin (2 things)
kept in a glass bottle to help minimize moisture
kept in dark container because sensitive to sunlight!
What are the four Vasodilator: Calcium Channel Blockers?
- Dihydropyridine: Amlodipine
- Dihydropyridine: Nifedipine
- NonDihydropyridine: Dilitiazem
- NonDihydropyridine: Verapam
Is Amlodipine a nonDihydropyridine or Dihydropyridine?
Dihydropyridine
MOA of Amlodipine
Vasodilation due to blocking calcium channels in vascular smooth muscle and myocardium
Indications of Amlodipine
Angina
HTN
Common SE of Amlodipine (2)
Peripheral edema
ELDERLY HYPOTENSION
Dx-Dx interactions of Amlodipine and Nifedipine
Grapefruit juice
what can Amlodipine be used instead of
Beta Blockers
Is Nifedipine a Dihydropyridine or nonDihydropyridine
Dihydropyridine
MOA of Nifedipine
Vasodilation due to blocking calcium channels in vascular smooth muscle and myocardium
Indications of Nifedipine
Angina
HTN
sound familiar?
Common SE of Nifedipine (3)
Palpitations
peripheral edema
ELDERLY HYPOTENSION
what is Nifedipine most likely to do?
Most likely to produce hypotension
is Diltiazem a Dihydropyridine or nonDihydropyridine
nonDihydropyridine
MOA of Diltiazem
Dilate coronary arteries and decrease myocardial oxygen demands
indications of Diltiazem (5)
1) Angina
2) HTN
3) A FIB
4) A FLUTTER
5) PSVT
SE of Diltiazem
Edema
what has the contraindications of both Bradycardia and SSS if no pacer
Nondihydropyridine’s
Diltiazem and Verapamil
What can you not use in combo with Diltiazem
Not for combo use with Beta blockers
What increased the half life of Diltiazem
half life increased in cirrhosis
is Verapamil a nondihydropyridine or dihydropyridine
nondihydropyridine
MOA of Verapamil
Dilate coronary arteries and decrease myocardial oxygen demands
sound familiar?
indications of Verapamil (3)
PSVT
A fib
A flutter
SE of Verapamil (1)
Gingival hyperplasia
Dx-Dx interactions with Verapamil
Grapefruit juice
What can you not use Verapamil in combo with
Beta Blockers
it will decrease nodal conduction!
What are the selective (B1) beta blockers
- Metoprolol Tartrate/ Metoprolol succinate
2. Atenolol
MOA of Metoprolol Tartrate/ Metoprolol succinate
Selective B1 adrenergic receptor inhibitor
Indications of selective (B1) beta blockers
Angina
HTN
hemodynamically stable MI
SE of selective (B1) beta blockers (6)
- fatigue
- sleep disturbance
- depression
- bradycardia
- rebound angina/hypertension
- hypotension
Contraindications for selective (B1) beta blockers (4)
- bradycardia
- heart block
- uncompensated heart failure
- severe depression
What can high doses cause in selective (B1) beta blockers
High doses can lose B1 selectivity
what do you do Post MI or in compensated HF with selective (B1) beta blockers… what about when stopping?
up titrate slowly
when stopping? down titrate slowly
which Beta blocker drug has an increase absorption with food?
Metoprolol Tartrate/ Metoprolol succinate
MOA of Atenolol
Selective B1 adrenergic receptor inhibitor
when do you adjust the dose of Atenolol
Adjust dose in CKD (50% renally excreted unmetab)
Non-selective (B1 and B2) : Beta blockers
Propranolol
MOA of Propranolol
Adrenergic B1 and B2 receptor inhibitor
Reduction in myocardial oxygen demand
indications of Propranolol
Tachyarrhythmia
Essential Tremor
migraine Px
anxiety
the 3 SE of Propranolol
fatigue
sleep disturbance
depression
contraindications of Nonselective Beta blockers (6)
- Hypersensitivity
- Bradycardia
- Heart Block
- Uncompensated heart failure
- Severe depression
- Bronchospasm
what may increase or decrease concentration of Propranolol
Ethanol aka alcohol
what may Propranolol mask
may mask hypoglycemia
what do we have to know about HR relate to Propranolol
what about when stopping
titrate to HR 50-60 bpm or increase HR 20 bpm with exercise
when stopping: down titrate
when does the bioavailability increase in Propranolol and by how much
Bioavail increases x2 in elderly
drug class of Carvediliol
Beta blocker: Non selective (B1 , B2, Alpha 1)
MOA of Carvediliol
Mixed alpha beta receptor inhibition
indications of Carvediliol
angina (off label)
HTN
Stable HF
Stable Post MI
SE of Carvediliol (hint … youve seen this before)
- fatigue
- sleep disturbance
- depression
- bradycardia
- rebound angina/hypertension
- hypotension
when do you titrate slowly in Carvediliol
Post MI or Compensated HF
Anti-anginal Agent: Miscellaneous
Ranolazine
MOA of Ranolazine
Inhibits inward sodium channel in ischemic cardiac myocytes during repolarization thereby reducing Na+/Ca++ exchange which relaxes cardiac muscle and reduces myocyte oxygen consumption (proposed mechanism)
Indication of Ranolazine
CHRONIC ANGINA
SE of Ranolazine
HYPERHYDROSIS
also: constipation, HA, bradycardia, hypotension etc
Contraindications of Ranolazine (2)
- any degree of hepatic cirrhosis
2. concurrent strong CYP3A4 inhibitors or inducers
Common dx-dx interactions with Ranolazine
- CYP3A4 inhibitors (diltiazem, eythromycin, verapamil etc)
- P-glycoprotein inhibitors (cyclosporine)
- simcastatin (max dose is 20mg/day)