CV module 1 Flashcards
Module 1: Review of Cardiovascular A & P and Pathophysiology
Anatomy and Physiology of the Heart
- The heart
o Muscular, _______(1) pump
o Sits _______(2) in chest
o Protective _______(3)
- Pair of _______(4)
- Pair of _______(5)
- 4 _______(6) valves
- _______(7) and veins
- Electrical _______(8) system
Answers:
1. hydraulic
2. left-middle
3. covering
4. atria
5. ventricles
6. unidirectional
7. Arteries
8. Conduction
Pericardium
- Consists of two parts:
- _______(1) Portion: tough, loose-fitting, inelastic sac around the heart
- _______(2) Portion:
- Parietal layer: lining inside the _______(3) pericardium
- Visceral layer (_______(4)): adheres to the outside of the heart
- _______(5) Space: lies between the parietal and visceral layers
Answers:
1. Fibrous
2. Serous
3. fibrous
4. Epicardium
5. Pericardial
Heart Wall
- Epicardium :
o outer layer of the heart wall; also called the _______(1)
- Myocardium:
o Thick, contractile, middle layer of specially constructed and arranged cardiac muscle cells
o If the myocardium is damaged this can cause a “myocardial _______(2)”
- Endocardium
o Lining of the interior of the myocardial wall and covers the trabeculae _______(3) (these help add force to the inward contraction of the heart wall)
Cardiac Muscle Fiber
- Principle location:
o wall of the _______(4)
- Principle function:
o _______(5) blood
- Type of control:
o _______(6)
Answers:
1. serous pericardium
2. infarction
3. carnae
4. heart
5. pumping
6. Involuntary
Structural Features of the Cardiac Tissues
- Structural Features:
- Nucleus: Single (sometimes double); near the center of the cell
- Striations: _______(1)
- T tubules: large diameter; form _______(2) with the SR, regulate _______(a) entry into sarcoplasm
- Sarcoplasmic reticulum: less extensive than in skeletal muscle
- Cell junctions: intercalated disks (gap junctions and desmosomes)
- Contraction style: Syncytium (mass) of fibers compress the heart chambers in slow, separate contractions (does not exhibit tetanus or fatigue); exhibits _______(3)
Structural Features of the Cardiac Tissues
- Structural Features:
- Nucleus: Single (sometimes double); near the center of the cell
- Striations: _______(1)
- T tubules: large diameter; form _______(2) with the SR, regulate Ca(^{++}) entry into sarcoplasm
- Sarcoplasmic reticulum: less extensive than in skeletal muscle
- Cell junctions: intercalated disks (gap junctions and desmosomes)
- Contraction style: Syncytium (mass) of fibers compress the heart chambers in slow, separate contractions (does not exhibit tetanus or fatigue); exhibits _______(3)
Answers:
1. present
2. diads
a. Ca++
3. autorhythmicity
Cardiac Myocyte Anatomy and Function
- Sarcolemma
- _______(1) membrane of the cardiac muscle
o Bilayer lipid membrane containing ion channels (_______(2)), active and passive ion transporters (ATPase, _______(3)), receptors (beta, _______(4) cholinergic, adenosine), and transport enzymes (glucose transporter)
o _______(5) (“T”) tubules: deep invaginations, penetrate the myoplasm and facilitate rapid, synchronous transmission of cellular depolarization
Answers:
1. External
2. Na+, K+, Ca2+, Cl-
3. Na+/K+
4. muscarinic
5. Transverse
Cardiac Myocyte
- Mitochondria: generates ATP required for contraction and relaxation
- _______(1): contractile unit of the cardiac myocyte
o Contains myofilaments in parallel-cross striated bundles of thin (actin, tropomyosin, troponin complex) and thick (myosin and proteins) fiber
o Connected in a series, have long and short axes and simultaneously shorten and thicken during contraction
o A-band contains _______(2) and thin filaments
o I-band contains _______(3) filaments only
o Z-line
Answers:
1. Sarcomere
2. thick
3. thin
Functional Anatomy of the Heart
- Right and Left Atria
o 2 thin, overlying sheaths of muscle
o Oriented at right angles to each other
- Ventricles
o 3 interdigitating spiral muscle layers
- Deep _______(1)
- Superficial _______(2)
- Superficial _______(3)
Answers:
1. sinospiral
2. sinospiral
3. bulbospiral
Atria (Receiving Chambers)
- Left and Right chambers separated by interatrial _______(1)
- Alternatively relax and contract to receive blood, then push it into the lower chambers
- Atria don’t need to generate great pressures to move blood small distances so the myocardial wall of each atria is _______(2)
- _______(3)
Answers:
1. septum
2. thin
3. Auricle
Supporting Role of the Atria
- Facilitate transition between low pressure venous to high pressure arterial blood flow
o _______(1)
o _______(2)
- _______(3) chambers
- Atrial contraction
- Establishes final ventricular SV at end-diastole (normally contributes _______(4) of this volume)
- Absent or ineffective (_______(5)/Flutter)
- Increased activity or stress may decrease/limit CO (decreased ABP, fatigue, syncope, exertional dyspnea or acute heart failure)
Answers:
1. Reservoirs
2. Conduits
3. Contractile
4. 15-20%
5. Afib
Functional Anatomy of the Heart
- Ventricular Muscle Layers
o _______(1) and _______(2) layers: perpendicular, oblique, and helical routes from the base to the apex
- Shorten the longitudinal axis of the LV
- Pulls the _______(3) of the heart toward the base
- Systolic “twisting” or “wringing” motion of the fibers
- _______(4)-myocardium: circumferential layers
o Reduce the _______(5) diameter
o Constricts the lumen, especially the LV
Answers:
1. Subendocardial
2. Subepicardial
3. apex
4. Mid
5. LV
Ventricles (Pumping Chambers)
- Right Ventricle
o Large volumes of blood, movement at low pressure
o Free wall of the RV shortens against the IV septum and LV
o Receives venous blood from the RA via the _______(1) and _______(2)
- Low pressure _______(3) mmHg
- O2 saturation _______(4)%
o Blood flows from the RV through the pulmonary circulation (low resistance)
o Unable to generate the same magnitude of stroke work as the LV
o Accommodates volume overload more easily than LV
- Left Ventricle
o _______(5) pressure system
o LV stroke volume (SV) is equal to the RV
o Pressure-volume work (stroke work) is _______(6)
o Thicker myocardium
Answers:
1. SVC
2. IVC
3. 2-10
4. 60-70
5. High
6. 4.5-7X >RV
Valves (Unidirectional Flow Valves)
- Atrioventricular Valve:
o _______(1) Valve
o _______(2) Valve
- Semilunar Valves:
o _______(3) valve
o _______(4) Valve
Answers:
1. Tricuspid
2. Mitral
3. Pulmonary
4. Aortic
Palpable Point of Maximal Impulse (PMI)
- Point in the chest where impulse of left ventricle is strongest
- Also called the _______(1) Impulse
- Normally palpable
o _____A.Intercostal space (ICS)
o _______(2) line
- PMI not where it _______(3) be?
o lateral or below 6th ICS can mean _______(4)
o Greater than 2cm in size: _______(5) or dilation
o Right sternal border: _______(6) or situs inversus
Anatomy of Coronary Blood Flow (CBF)
- Myocardial blood supply entirely from Right and Left Coronary Art.
- Blood flows from epicardial to endocardial vessels
- Coronary sinus and Anterior cardiac veins
Thesbian veins
Answers:
1. Apical
A. 5th
2. Midclavicular
3. should
4. ventricular enlargement
5. ventricular hypertrophy
6. dextrocardia
Mechanics of Coronary Blood Flow (CBF)
- Blood flow to the LV
o Directly dependent on the difference between _______(1) and the _______(2) (CPP)
o Inversely related to the _______(3) to flow
- Coronary Perfusion Pressure (CPP)= _______(4)
o Difference between the _______(5) pressure and the ____ pressure
o Art. Diastolic pressure is more important than MAP in determining myocardial blood flow
- Reduced CPP
o Decreased _______(6) pressure?
o Increased_______(7) pressure?
o Increase in _______(8) (reduction in diastolic time) vs?
- During contraction, intramyocardial pressures in the LV get close to systemic arterial pressure
- When that happens, the force of LV contraction can almost totally occlude the intramyocardial portion of the coronary arteries
- _______(9) is almost completely perfused during diastole
- _______(10) is perfused during systole and diastole
- Greatest intramural pressure during systole affects the a.____ thus making it most vulnerable to ischemia during decreases in Coronary Perfusion Pressure (CPP)
Answers:
1. Aortic pressure
2. LVEDP
3. vascular resistance
4. Arterial diastolic pressure –LVEDP
5. Aortic and Ventricular
6. Aortic pressure
7. LVEDP
8. HR
9. LV
10. RV
a. endocardium
Control of Coronary Blood Flow
- Coronary Blood flow normally _______(1) ml/min (average adult male)
- Myocardium regulates perfusion pressures between _______(2) mm Hg, beyond that blood flow becomes pressure dependent
- Changes in blood flow
o Hypoxia: causes coronary vasodilation
o Sympathetic stimulation increases myocardial blood flow from increased demand and _______(3) predominance activation (receptor?)
o _______(4) and _______(5) present in coronary arteries (receptors?)
Answers:
1. 250
2. 50-120
3. B2
4. Alpha1
5. Beta2