Cuyco HFpEF

Question 1

Predominant pathophysiologic cause of HFpEF?

Answer 1

Abnormal diastolic function (relaxation and stiffness)

Question 2

LVEF diagnostic criteria for HFpEF?

Answer 2

> 50%

Question 3

LVEDVI diagnostic criteria for HFpEF?

Answer 3

<97 ml/m2

Question 4

LVEDP diagnostic criteria for HFpEF

Answer 4

> 16 mmHg

Question 5

PCWP of HFpEF patients?

E/E’?

Answer 5

12 mmHg

E/E’ >15 or >8 + NT-proBNP >220 pg/ml

Question 6

This coresponds to the period beginning at the end of the ventricular ejection (closure of semilunar valves) extending to the closure of the AV valves?

Answer 6

Diastole or ventricular filling

Question 7

Diastolic function is influenced by what factors?

Answer 7

Myocardial relaxation
ventricular filling
Ventricle’s passive elastic properties
Heart rate

Question 8

Parameters of diastolic function

Answer 8

Ventricular relaxation
Myocardial chamber compliance
Filling pressure

Question 9

Classification of diastolic filling abnormalities

Answer 9

Abnormal relaxation
Restrictive physiology
Pseudonormalisation

Question 10

A transition from abnormal relaxation to restrictive physiology
Decreased LV compliance+ moderate increase in LA pressure + abnormal relaxation profile

Answer 10

Pseudonormalisation

Question 11

Maneuver that can unmask abnormal relaxation by reducing LA pressure

Answer 11

Valsalva - adequate if 10% reduction in the maximal E velocity is achieved

Question 12

An increase in the size of this chamber signifies chronic diastolic dysfunction?

Answer 12

Left atrium