Cushing Syndrome Flashcards
1
Q
What is Cushing syndrome
A
Cushing syndrome is the best excess of free glucorticosteriod in the bodybmade from the adrenal gland - cortisol
2
Q
Symptoms
A
Moon face Buffalo hump Kyphosis Weight gain Insnomnia Frontal balding Hair growth Acne Stretch mark on stomach HTN Polyuria Diabetes Waist line obesity proximal myopathy Pigmentation Ammenorrhoea Reduced libido Depression
3
Q
Risk factors
A
Osteoporosis Obesity Diabetes Steroid use Females Hypertension
4
Q
Diagnosis
A
Dexamethasone test
24 hr urinary cortisol test
MRI
X-ray
5
Q
Prognosis
A
50% 5 year mortality if untreated
6
Q
Cause
A
60%. Elevated ACTH due to pit gland tumou o dysfunction
Adrenal tumour in 15% causing elevated coristol so decreases ACTH
7
Q
Management
A
Ketconazole Methrapone Mitane Surgery Treat cause
