Cushing's Syndrome

Question 1

What is Cushing’s Syndrome

Answer 1

Collection of signs + symptoms related to long exposure to cortisol with Endogenous + Exogenous causes

Question 2

What is an example of a exogenous cause of Cushing’s syndrome

Answer 2

Iatrogenic => Glucorticoids for Asthma

Question 3

What are the 2 types of Endogenous causes of Cushing’s Syndrome

Answer 3

ACTH Dependent

ACTH Independent

Question 4

What are 2 causes of ACTH Dependent cause of Cushing’s

Answer 4

Pituitary Adenoma

Ectopic ACTH from Small Cell Lung Cancer

Question 5

What are 4 causes of ACTH Independent cause of Cushing’s

Answer 5

CARS

C ancer => Adrenal Adenoma

A drenal Nodular Hyperplasia

R are => McCune-Albright Syndrome

S teroid use => Prednisilone

Question 6

what are 4 characteristic signs of Cushing’s

Answer 6

Moon Face

Central Obesity

Buffalo Hump

Striae

Question 7

What are the 2 investigations used in Cushing’s

Answer 7

BT // Urinary free cortisol

CXR => small lung cancer

Question 8

What are 4 complications that can arise from Cushings

Answer 8

HTN
Cataracts

DM
Osteoporosis

Question 9

What environmental factor increase Cortisol levels and thus Px are told to avoid it in Cushings

Answer 9

Alcohol => Inc. Cortisol

Question 10

What are the 3A’s of Cortisol (actions)

Answer 10

m A ke Glucose

A nti-stress

A nti-inflammatory