cumulative Flashcards
what is the role of a neuron?
Neurons work in unison with one another to produce functions
role of dendrites/cell body?
Receive information from other neurons
what is the post-synaptic site?
the dendrites and cell body
what is the pre-synaptic site?
axon terminals
what does post-synaptic site mean?
- Receiving end of the synapse
- Contains receptors to bind neurotransmitter
what does pre-synaptic site mean?
- Sending end of the synapse
- Filled with neurotransmitter
what is the role of the axon?
to carry the message from the input zone to the output zone
what is the role of the axon terminals?
Sends the message on to other cells
what is the threshold of excitation?
- Change in voltage at hillock (depolarization)
- Change opens voltage-gated Na+ channels
- Change is around 5m (-70mV to -65 mV)
step one of the action potential
- Voltage-gated Na+ channels open
- Na+ rushes in
- Cell rapidly depolarizes
step two of the action potential
- Voltage-gated K+ channels open
- K+ starts to leave the cell
- Contributes to the cell hyperpolarizing (Not immediately noticeable because of Na+)
step three of the action potential
- Na+ channels close at Na+ equilibrium (+ 50mV)
- Cell begins to hyperpolarize
- Na+ isn’t rushing in
- Na+/K+ pumps are pushing Na+ out
- K+ is still leaving via its open channels
step four of the action potential
- K+ channels finally close slowly
- Cell hyperpolarizes: overshoots the resting potential
- Eventually cell comes to the resting potential
what is the synapse?
Two cells communicate with one another via a chemical messenger
what is the goal of the pre-synaptic cell?
get neurotransmitter into the synaptic gap
what is the goal of the post-synaptic cell?
cause a ‘yes’ or ‘no’ signal
Glutamate (Glut)
- Major excitatory neurotransmitter
- MDMA receptors
- involved in learning and memory
- Involved in excitotoxicity
- Can happen in injury or stroke