CTE Flashcards
1
Q
symptoms of CTE
A
-headache, decrease attention, decrease STM
-behavioral changes, rage
-depression, suicidality, dementia, gait/motor abnormalities
2
Q
primary injury
A
axonal chearing> release of Tau
3
Q
2ndary injury
A
neuro inflammation, (mitochondrial dysfunction, cytoskeleton degeneration, oxidative stress)>activate microglia>glial scar>CTE
4
Q
P-Tau enters
A
ER> irregular fold of protein, decrease protein synthesis> decrease signaling> CTE
5
Q
Tauprotein>
A
Phosphorylation>p-tau
6
Q
Ptau>
A
contagious> increase P-tau> tangles Plaques >CTE
