CTD- Sjogrens syndrome

Question 1

What is sjorgens syndrome (2)

Answer 1

autoimmune condition characterized by lymphocytic infiltrates in exocrine organs

primary condition or can occur secondary to other autoimmune conditions like RA and SLE.

Question 2

Symptoms (6)

Answer 2

dryness of the eyes and mouth (sicca symptoms).

arthralgia

fatigue

vaginal dryness

parotid gland swelling.

Question 3

Diagnosis- antibodies + test (4)

Answer 3

based on the confirmation of ocular dryness (Schirmers test)= positive vital dye staining results

positive anti-Ro and anti-La antibodies

typical features on a lip gland biopsy.

Question 4

Management- non pharma (3)

Answer 4

symptomatic

Lubricating eyedrops are used and saliva replacement products may be tried.

Regular dental care

Question 5

Management - pharma (3)

Answer 5

Pilocarpine - stimulate saliva production but often causes side effects such a flushing.

Hydroxychloroquine -help with arthralgia and fatigue.

Other immunosuppression would usually only be used in the context of organ involvement e.g. interstitial lung disease.