Autoimmunity

Question 1

Auto-antibodies

Answer 1

antibodies generated by the immune system against the body’s own proteins, usually within cells.

auto-antibody production is characteristeric of many rheumatological conditions. These tend to be referred to as seropositive conditions (auto-antibodies in serum).

Question 2

Anti-CCP antibody

Answer 2

Rheumatoid arthritis

Question 3

Anti-nuclear antibody (ANA)

Answer 3

SLE, Sjogrens syndrome, Systemic sclerosis, MCTD,

Question 4

Anti-double stranded DNA antibody (dsDNA)

Answer 4

SLE

Question 5

Anti-Sm

Answer 5

SLE

Question 6

Anti- Ro

Answer 6

SLE, Sjogrens syndrome

Question 7

Anti-La

Answer 7

Sjogrens syndrome

Question 8

Anti-centromere antibody

Answer 8

Systemic sclerosis (limited)

Question 9

Anti-Scl-70 antibody

Answer 9

Systemic sclerosis (diffuse)

Question 10

Anti-RNP antibody

Answer 10

SLE, Mixed connective tissue disease (MCTD)

Question 11

Anti-Jo-1 antibody

Answer 11

Myositis

Question 12

Anti-cardiolipin antibody and lupus anti-coagulant

Answer 12

Anti-phospholipid syndrome

Question 13

Anti-neutrophil cytoplasmic antibody (ANCA)

Answer 13

Small vessel vasculitis (GPA, EGPA, MPA)