CT

Question 1

_ CT in skin
_ CT in tendons

Answer 1

• Loose
• Fibrous

Question 2

ECM is _ + _

Answer 2

• Protein fibers, ground substance

Question 3

Strongest cartilage is _

Answer 3

Fibrocartilage

Question 4

Most numerous CT is _

Answer 4

Fibroblasts

Question 5

_ secrete protein fibers and ground substance
_ is the inactive form

Answer 5

• Fibroblasts
• Fibrocytes

Question 6

Macrophages are derived from

Answer 6

Blood cells(monocytes)

Question 7

Adipocytes are 2 types _, _

Answer 7

-Unilocular(white), multilocular(brown)

Question 8

_ occur in bone marrow and stimulate inflammation after injury

Answer 8

Mast cells

Question 9

Adult stem cells are 2 types

Answer 9

• Mesenchymal > replace CT after injury
• Hematopoietic > rise to all wandering cells

Question 10

_ most abundant fiber of CT and protein in body(30%)
It is composed of _

Answer 10

• Collagen
• Tropocollagen

Question 11

Type I collagen:
Type II:
Type III
Type IV:

Answer 11

• Heterotrimeric, CT proper
• Homotrimeric, cartilage
• Homo, Reticular fibers
• Homo, Basal lamina, no 68nm banding

Question 12

Classes of collagen(6):

Answer 12

-Fibrillar(1,2,3,5,11)
- FACIT(9,12,14,16)
- Hexagonal(8,10)
- Transmembrane(13,17,23)
- Multiplexins(15,18)
- Basement membrane(4,6,7)

Question 13

_ main source of collagen and secrete _

Answer 13

Fibroblasts, procollagen

Question 14

T/F: Synthesis of collagen is intracellular

Answer 14

False. Collagen molecule > intra
Fibrillogenesis > extra

Question 15

Elastic fibers made of (2)

Answer 15

• Central core elastin(desmosine, isodesmosine)
• Surrounding fibrillin

Question 16

Abnormal fibrillin expression >

Answer 16

Marfan syndrome

Question 17

_ helps bind cells to CT fibers
Mixture of _ + _

Answer 17

• Ground substance
• Proteoglycans, GAG’s

Question 18

Proteoglycans:
_ has 1 GAG
_ has +200 GAG’s
_ is membrane-bound
_, _ have identical GAG’s

Answer 18

• Decorin
• Aggrecan
• Syndecan
• Fibroglycan, versican

Question 19

_ responsible for physical properties of ground substance
Consist of
Examples …

Answer 19

• GAG’s
• GlcNac/GalNac + uronic acid
• Dermatan sulfate, hyaluronan

Question 20

T/F: All GAG’s are synthesized as post-translational covalent modifications of proteoglycans

Answer 20

False. Not hyaluronan. It is in the ECM as a free CBHY.
Binds proteoglycans by linker proteins

Question 21

Hyaluronan forms _ that is found in _

Answer 21

• Proteoglycan aggregates
• Cartilage ground substance

Question 22

_ stabilize ECM and connect it to cell.
Examples…

Answer 22

• Multi-adhesive glycoproteins
• Fibronectin, laminin, entactin

Question 23

T/F: ECM is cellular material around cells.

Answer 23

False. Non-cellular