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csv immuno Flashcards

1
Q

Adenylate kinase 2

A

Reticular dysgenesis

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2
Q

Gamma chain of Il-2R

A

X-linked SCID

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3
Q

22q11.2 deletion

A

DiGeorge syndrome

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4
Q

Defect of regulatory factor X or Class II Transactivator

A

Bare Lymphocyte Syndrome

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5
Q

Il-12R or IFNgamma deficiency

A

Susceptibility to TB, atypical mycobacteria, BCG, salmonella

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6
Q

Defective tyrosine kinase gene

A

Bruton’s X-linked hypogammaglobulinaemia

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7
Q

Mutation in CD40-L

A

Hyper-IgM snydrome

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8
Q

Causes of a tear drop cell

A

Iron deficiency

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9
Q

Causes of basophilic stippling

A

Beta thalassaemia trait, lead poisoning, alcoholism, sideroblastic anaemia

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10
Q

Causes of hypersegmented neutrophils

A

B12 deficiency, folate deficiency, Drugs

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11
Q

Causes of target cells or codocytes

A

Iron deficiency, thalassaemia, hyposplenism, liver disease

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12
Q

Howell-Jolly bodies

A

Hyposplenism

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13
Q

Scalopping on biopsy

A

Coeliac

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14
Q

Cyclosporine

A

Calcineurin inhibitor

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15
Q

Tacrolimus

A

Calcineurin inhibitor

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16
Q

Tofacitinib

A

JAK inhibitor for RA

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17
Q

Apremilast

A

PDE4 inhibitor for psoriatic arthritis

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18
Q

Use of rabbit anti-thymocyte globulin

A

Severe allograft rejection

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19
Q

Basiliximab

A

anti-CD25 for prophylaxis of allograft rejection

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20
Q

Abatacept

A

CTLA-4 Ig for RA

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21
Q

Rituximab

A

Anti-CD20 for Lymphoma, RA, SLE

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22
Q

Natalizumab

A

Anti-a4-integrin for MS, Crohn’s disease

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23
Q

Tocilizumab

A

Anti-Il-6R for RA, Castleman’s disease

24
Q

Infliximab

A

anti-TNFa for RA, ank spond, psoriasis, IBD

25
Q

Adalimumab

A

anti-TNA for RA, ank spond, psoriasis, IBD

26
Q

Certolizumab

A

Anti-Tna for RA, ank spond, psoriasis, IBD

27
Q

Golimumab

A

Anti-TNFa for RA, ank spond, psoriasis, IBD

28
Q

Etanercept

A

TNF-R p75 IgG fusion protein for RA, ank spond psoriasis

29
Q

Ustekinumab

A

Anti-Il-12 and anti-Il-23 for psoriasis

30
Q

Denosumab

A

anti-RANK-L for osteoporosis

31
Q

omab

A

Mouse antibody

32
Q

umab

A

Human anitbody

33
Q

ximab

A

Chimeric antibody

34
Q

imab

A

Primate antibody

35
Q

<350/uL

A

Neutropaenia, <500/uL

36
Q

5 y/o recurrent infections since birth + increased irritability + neutrophils 350/uL + normal NBT test

A

Kostmann syndrome

37
Q

4 /o recurrent chest infections + reduced B-cell count + low IgA, igM and IgG levels

A

Bruton’s X-linked agammaglobulinaemia

38
Q

48 y/o + diarrhoea for 3 weeks + blood + tired + fever + recurrent chest infections

A

Protein-losing enteropathy

39
Q

3 y/o + recurrent mild chest infections + cleft lip + reduced T-cell count + hypocalcaemia

A

DiGeorge syndrome

40
Q

4 y/o + recurrent chest infections + history of eczema + recurrent nose bleeds + reduced IgM + raised IgA and IgE

A

Wiskott-Aldrich syndrome

41
Q

Negative NBT test

A

Chronic Granulomatous

42
Q

4 y/o + mild but chronic diarrhoea + icteric sclera + hepatomegaly +Defect in MHC I

A

Bare lymphocyte syndrome

43
Q

Recurrent mild respiratory and GI infections

A

Selective IgA deficiency

44
Q

Hyperacute rejection

A

HLA-mismatching

45
Q

OKT3

A

Muromonab-CD3, mouse mAb targeting CD3

46
Q

Primary indication for OKT3

A

Acute corticosteroid-resistant rejection of renal, heart and liver transplants

47
Q

Reduced IgM, raised IgA and IgE

A

Wiskott-Aldrich syndrome

48
Q

Calcineurin inhibitor that causes gum hyperplasia

A

Cyclosporine

49
Q

Rheumatoid arthritis + deceased WBC + splenomegaly + recurrent infections

A

Felty’s syndrome

50
Q

Anti-smooth muscle Ab + cirrhosis

A

Autoimmune hepatitis type 1

51
Q

Anti-LKM-1

A

Autoimmune hepatitis type 2

52
Q

52 y/o + itchy skin + malaise + bruising on arms + legs

A

Anti-mitochondrial

53
Q

Lymphocyte destruction of bile cannaliculi of liver

A

Primary biliary cirrhosis

54
Q

saddle shaped nose

A

Granulomatosis with polyangitis (Wegener’s)

55
Q

c-ANCA

A

Granulomatosis with polyangitis (Wegener’s)

Rawa cram (5 decks)

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