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Rawa cram > Callans. > Flashcards

Callans. Flashcards

1
Q

Goodpastures

A

Type 2 hypersensitivity

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2
Q

Neutropenia risk high is TPMT low

A

Azathioprine

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3
Q

Recurrent infections with no neutrophils in FBC

A

Kostmann syndrome

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4
Q

1 yo boy. Recurrent bacterial infections. Cd4 and cd8 T cells present. B cells absent, IgG, IgA, IgM absent.

A

Brutons x linked hypogammaglobulinaemia

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5
Q

Infection with atypical mycobacterium. Normal fbc.

A

Ifn gamma receptor deficiency

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6
Q

Bonds to microbial surface carbohydrates to activate the complement cascade in an immune complex independent manner

A

Mbl

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7
Q

Binding of immune complexes to this protein triggers the classical pathway of complement activation

A

C1

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8
Q

PML

A

Mycophenolate mofetil

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9
Q

Derived from monocytes and resident in peripheral tissues

A

Macrophages

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10
Q

Recurrent respiratory tract infections, absent IgA, normal IgM and IgG

A

IgA deficiency

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11
Q

Express receptors that recognise peptides usually derived from intracellukar proteins and expressed in hla class 1 molecules

A

Cd8 T cells

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12
Q

Recurrent infections with hepatosplenomegalg and abnormal dihydrorhodamine test

A

Chronic granulomatous disease

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13
Q

Exist within the bone marrow and develop from haemotopoietic stem cells

A

Pre B cells

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14
Q

Lymphocytes that express inhibitory receptors capable of recognising hla class 1 molecules and have cytotoxic capacity

A

Nk cells

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15
Q

Eczema

A

Type 1 hypersensitivity

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16
Q

Osteoporosis

A

Prednisolone

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17
Q

May be mediated by antibodies, complement components or acute phase proteins and facilitates phagocytosis

A

Opsonisation

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18
Q

Inhibits T cell migration but may only be used in highly active remitting/ relapsing MS

A

Natalizumab (anti-a4 integrin)

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19
Q

Severe recurrent infections from 3 months, cd4 and cd8 T cells absent, nk cells absent, B cells present, igs low. Normal facial features and cardiac echocardiogram

A

X linked SCID

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20
Q

Reduce risk of TB infection

A

BCG vaccination

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21
Q

Chronic granulomatous disease

A

ifn Gamma

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22
Q

Cleavage of this protein may be triggered via the classical, mbl it alternative pathways

A

C3

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23
Q

Subset of lymphocytes that express foxp3 and cd25

A

T reg cells

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24
Q

Severe childhood onset SLE with normal levels of c3 and c4

A

C1q deficiency

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25
Q

Single gene mutation involving FOXp3 resulting in abrmonality of T reg cells

A

IPEX (immune dysregulation, polyendocrinopathy, enteropathy, x linked)

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26
Q

Is mediated by toll like receptors which recognise pathogen associated molecular patterns

A

Pattern recognition

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27
Q

Young adult with chronic infection with mycobacterium marinum

A

IFN gamma receptor deficiency

28
Q

Site of deletion of T cells with innaprorpaitely high or low affinity for HLA molecules and of maturation of T cells into cd4+ or cd8+ cells

A

Thymus

29
Q

Treatment options include inhibition if IL6, TNF alpha and depletion of B cells

A

Rheumatoid arthritis

30
Q

Post transplant lymphoproliferative disorder

A

EBV specific CD8 T cells

31
Q

Recurrent bacterial infections in a child, episode of pneumocystis pneumonia, high IgM, absent IgA and IgG

A

X linked hyper IgM syndrome due to cd40 ligand mutation

32
Q

Are generated rapidly following antigen recognistion and are not dependent on cd4 T cell help

A

IgM secreting plasma cells

33
Q

Recurrent infections when receiving chemotherapy but previously well

A

MBL deficiency

34
Q

Include both the bone marrow and thymus; sites of b and T cell development

A

Primary lymphoid organs

35
Q

Area within secondary lymphoid tissue where B cells proliferate and undergo affinity maturation and isotope switching

A

Germinal centre

36
Q

Meningococcus meningitis with fhx of sibling dying of the same condition

A

C7 deficiency

37
Q

Antibody specific for cd25 which inhibits T cell activation and is used to prevent rejection

A

Basiliximab (anti il2 receptor)

38
Q

Recurrent infections in childhood, abnormal facial features, congenital heart disease, normal B cells, low T cells, low igA and igG

A

DiGeorge syndrome

39
Q

Cell dependent on the presence of cd4 T cell help for generation

A

IgG secreting plasma cells

40
Q

Depleted B cells and is effective in treatment of B cell lymphomas and rheumatoid arthritis

A

Rituximab (anti cd20)

41
Q

Infertility

A

Cyclophosphamide

42
Q

Metastatic melanoma

A

Pembrolizumab (anti PD1)

43
Q

Recurrent infections with high neutrophil count on fbc but no abcess formation.

A

Leukocyte adhesion decifiency

44
Q

Immunosuppressed VZ seronegarive indicidual after chicken pox exposure

A

Varicella zoster immunoglobulin.

45
Q

May be mediated by bacteriocidal enzymes such as lysozyme

A

Non oxidative killing

46
Q

Treatment options include inhibition of IL12/23, TNF alpha and IL17A

A

Psoriasis

47
Q

Single gene mutation involving MEFV and affective the inflammasome complex, resulting in recurrent episodes of serositis

A

familial Mediterranean fever

48
Q

Part of the final common pathway resulting in the generation of the membrane attack complex

A

C9

49
Q

Bonds to CD80 and CD86 on antigen-presenting cells and inhibits T cell activation and is effective in Rheumatoid arthritis

A

Abatacept (VTLA4-ig fusion protein)

50
Q

X Linked scid

A

Bone marrow transplantation

51
Q

Subset of cells that express cd4 and secrete ifn gamma and il2

A

Th1 cells

52
Q

Carries lymphocytes from lymph nodes back to the blood circulation

A

Thoracic duct

53
Q

Nephrotixicity

A

Tacrolimus

54
Q

Multiple sclerosis

A

Type 4 hypersensitivity

55
Q

Polymorphonuclear cells capable of phagocytosing pathogens and killing by oxidative and non oxidative mechanisms

A

Neutrophils

56
Q

Divalent antibody present within mucous which helps provide a constitutive barrier to infection

A

IgA

57
Q

Immature cells are adapted for pathogen recognition and uptake whilst mature cells are adapted for antigen presentation to prime T cells

A

Dendritic cells

58
Q

Membranoproliferative neohritis and bacterial infections

A

C3 deficiency with presence of nephritic factor

59
Q

Play an important role in promoting germinal centre reactions and differentiation of B cells into igg and iga secreting plasma cells

A

T follicular helper (tfh) cells

60
Q

SLE

A

Type 3 hypersensitivity

61
Q

6 month baby with two recent serious bacterial infections. T cells present - but only cd8+ population. B cells present. IgM present but igG low

A

Bare lymphocyte syndrome type 2

62
Q

Mutation within the Fas pathway associated with lymphocytosis, lymphomas and auto immune cytopenias

A

Auto immune lymphoproliferatice syndrome (ALPS)

63
Q

Inhibits function of lymphoid and myeloid cells and used in management of rheumatoid arthritis

A

Tocilizumab (anti il6 receptor)

64
Q

Describes killing mediated by reactive oxygen species generates by action of the nadph complex

A

Oxidative killing

65
Q

Adult with bronchiectasis, recurrent sinusitis and development of atypical SLE

A

Common variable immunodeficiency

66
Q

Treatment options include inhibition if RANK ligand

A

Osteoporosis

67
Q

X linked hyper IgM syndrome

A

Human normal immunoglobulin

Rawa cram (5 decks)

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