csv-export (2) Flashcards
psychosis
decreased ability to evaluate accuracy of perceptions and thoughts?? make incorrect inferences about external reality
positive symptoms of psychosis
hallucinations (false perceptions in absence of real sensory stimuli)?? can be any of the senses, but auditory is most common
delusion (fixed false belief that you maintain in the face of considerable evidence of the contrary)
disorganization? loose associations/derailment: thought production where there is no recognizable relationship between ideas
how are delusions organized?
by content
paranoid, grandiose, nihilisitc (belief you are dead), erotomanic
neologisms
making up words
echolalia
repeating sounds of phrases
negative symptoms of psychosis (5 As)
affective flattening: unchanging facial expression, decreased expressive gestures, poor eye contact, affect nonresponsivity, lack of vocal inflections
alogia: poverty of speech
avolition?apathy?? dec. grooming/hygiene, impersistance at work/school
anhedonia?associality?dec interests/activities, dec interest in sex/intimacy/closeness
attention deficits? social/testing inattentiveness
cognitive impairment in psychosis
processing speed, attention, working memory, reasoning/executive function, verbal comprehension, social cognition
precedes onset of positive symptoms
perform 1?2 standard deviations below healthy controls on neuropsych testing
schizoaffective disorder
primary psychotic disorder that also has depression/bipolar
brief reactive psychosis
less than 1 month
schizophreniform disorder
greater than 1 mo but less than 6 mo duration of symptoms
delusional disorder
only have delusions, no other symptoms of psychosis
schizophrenia diagnosis
active phase: at least 2 psychotic symptoms (delusions, hallucinations, thought disorg, catatonia, negative symptoms) for at least one month, continous signs of disturbance for at least 6 months
needs to markedly impair ability to function
no known etiology
risk factors for schizophrenia
first generation immigrants born late winter?early spring (inflammatory response) OB complications living in urban area advanced paternal age cannabis use early on
what are structural brain abnormalities with schizophrenia?
enlarged ventricles lead to more negative symptoms and poor prognosis
reduced volume of temporal limbic structures
REDUCED metabolic activity in frontal lobes
INCREASED activity in temporal lobe limibc structures
abnormalities in NT in schizophrenia
drugs that enhance DA activity can cause psychosis
all antipsychotics block DA receptors
altered levels of DA metabolites in CSF
glutamate: PCP/ketamine model of schizo, hypo?NMDA receptor hypotehsis
GABA
acetylcholine
what are bad prognostic factors for schizo?
insidious onset continuous course earlier age of onset prominent neg symptoms female enlarged lateral and 3rd ventricles
better prognostic factors for schizo?
acute onset episodic course later age of onset primarily positive symptoms male gender
emotion
internal state of feeling that may or may not be reflexted by outward behavior (based on the moment, days activities, etc)
mood
an internal state of sustained feelings that has direct or indirect effects on outward behavior
affect
a collection of observed behaviors that reflect an underlying mood or emotion
what are predisposing factors in mood disorders?
if parent has it, you have 10?25% risk
concordance rate is 50?70% among twins
serotonin receptor polymorphisms
life events?? childhood illness, abuse, unemployment, death of parent, social isolation
major depressive disorder
for 2 weeks, you have low mood/anhedonia + weight loss/gain slowed movements fatigue/loss of energy poor concentraiton worthlessness/inappropriate guilt insomnia/hypersomnia
whats the mnemonic for MDD?
S? sleep disturbance
I? interest/pleasure reduction
G? guilt
E? energy loss
C?conc impairment
A? appetite changes
P? psychomotor changes
S?suicidal thoughts
duration of MDD
untreated: 6?13 mo
treated: 3 mo
85% recurrence rate, mostly in first 5 yrs