Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Course 2-rheum > Crystal arthropathies > Flashcards

Crystal arthropathies Flashcards

1
Q

which type of crystal arthropathy has a Tx?

A

gout

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the etiology of gout?

A

men and postmenopausal women, acute inflammatory, complicated by DM, HTN, heart disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the clinical features of gout?

A
  • hyperuricemia (underexcretion)
  • acute monoarticular arthritis (over Dx)
  • acute polyarticular arthritis (under Dx)
  • tophi and chronic arthritis
  • nephrolithiasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

where is gout most likely to happen? why?

A

big toe; high hydrostatic pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are risk factors for gout?

A

obesity, seafood/meat, ETOH, high fructose corn syrup

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the main cause of gout?

A

primary underexcretion (highest incidence in Mauis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the most common cause of secondary underexcretion in gout?

A

chronic renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

where is uric acid excreted?

A

2/3 kidneys, 1/3 stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

____is necessary but not sufficient for gout

A

hyperuricemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the most likely DDx for gout?

A

septic arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what substance is implicated in pseudogout?

A

calcium pyrophosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what condition is likely to result in pseudogout?

A

hereditary hemochromatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

should Dx of gout be based on serum uric acid alone? why?

A

no; serum rates decreased during acute flare (urate crystals not measured in serum urate, acute inflammation lowers urate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

when should serum urate be measured?

A

2wks after acute attack

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MSU crystals indicate___

CPPD crystals indicate___

A

gout (negative birefringement)

pseudogout (positive birefringement)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the criteria on the score system for gout?

A
  • male
  • previous arthritis attack
  • onset in <1day
  • joint redness
  • MTP1 involved
  • HTN or CVD
  • serum uric acid >350ul
17
Q

what XR features are found in gout?

A

erosion w overhanging edges, cloudy XR, rate bite lesions

18
Q

what tests are used to pick up MSU deposits in gout?

A

DECT or GSI-CT

19
Q

what are the goals of Tx for gout?

A
  • prevent attacks
  • prevent urate grystal deposition
  • prevent complications (amputation)
  • prevent comorbidities (CV, metabolic)
20
Q

what is the goal of acute Tx for gout?

A

exclude septic arthritis, suppress pain and inflammation

21
Q

what concentration of serum urate is the target in chronic gout Tx?

A

<360ul (avoid progression and complication)

22
Q

what are examples of uric acid lowering agents?

A

allopurinol, febuxostat, probenecid

23
Q

what can cause secondary overproduction in gout?

A

lyphoproliferative diseases, hemolytic anemia, psoriasis

24
Q

what usually precedes gout attacks?

A

intra-articular tophi

25
Q

what are the features of chronic gout?

A

> 2 flares/yr, tophi, uric acid overproduced, Hx kidney stones, severe polyarticular/persistent flares, chronic synovitis

Course 2-rheum (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions