Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IS LAB SEMIS CRP & ASO > CRP > Flashcards

CRP Flashcards

1
Q

Crucial biomarkers for inflammation and infection

A

C-REACTIVE PROTEIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

they are responses provided by immune response if inflammation
or infection is encountered.

A

Acute-phase reactants/proteins (APRs/APPs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

primary inducer for inflammatory
response

A

Interleukin 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

responsible for activating acute-phase
protein

A

Interleukin 6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CRP are synthesized in the

A

LIVER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

CRP Normal range:

A

<10mg/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

If the value is greater than 10mg/L, the body is having what?

A

inflammation or infection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the difference between POSITIVE AND NEGATIVE APPs

A

Negative acute phase protein
“decreases” in inflammation

Positive acute phase protein
“increases” in inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

more inflammation in the body causes

A

higher CRP level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T OR F
CRP is very specific

A

F
not specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CRP tests can help monitor ____________ and ___________

A

disease progress & flares

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

An extremely elevated CRP is suggestive of a possible ___________. (>1000mg/L)

A

bacterial
infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CRP gene is found on

A

chromosome 1, short arm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CRP has the highest affinity for

A

─ Phosphocholine on bacteria

─ Mixture of sphingomyelin and phosphatidylcholine in eukaryotic membranes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T or F
CRP can recognize both intrinsic and extrinsic ligands

A

T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

3 Functions of CRP

A

Anti-infective
Anti-inflammatory actions
Scavenging Action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Differentiate CRP and ESR based on the following:

Production
Sensitivity
Specificity
Reference range

A

CRP
rapid, more sensitive, more specific, mg/L

ESR
delayed, moderately sensitive, less specific, mm/h

17
Q

A function of CRP the is characterized by binding avidly to cell that are undergoing apoptosis or necrosis.

A

Scavenging Action

18
Q

PROCESSES INDUCED BY CRP

OPERA V

A

Activation of complement cascade
RAAS activation
Vascular wall damage
Prothrombotic state
Endothelial dysfunction
Opsonization of oxidized LDL

19
Q

FACTORS AFFECTING CRP LEVELS

A

Gender
Body mass effect
Ethnicity
Exercise
Alcohol consumption

20
Q

T or F
Women have higher CRP levels than men

A

T

21
Q

T or F
The higher the weight, the lower level of CRP

A

F
the higher

22
Q

T or F
After exercise CRP levels decrease

A

T

23
Q

METHODS FOR DETECTION OF CRP

(VIRE)

A

Visual agglutination
Immunoturbidimetry
Rapid immunodiffusion
ELISA

24
Q

Utilizes antigen-antibody interaction on a solid surface

A

ELISA

25
Q

Relies on the formation of antigen-antibody complexes causing turbidity

A

Immunoturbidimetry

26
Q

Based on immunoprecipitation, where CRP diffuses towards specific antibodies in a gel medium, forming visible precipitin
bands

A

Rapid immunodiffusion

27
Q

Involves the clumping of latex particles coated with CRP specific antibodies

A

Visual agglutination

28
Q
  • Osteoarthritis
  • Predictive coronary events (esp. in stable angina)
  • Proinflammatory or prothrombotic effects
A

Elevated CRP levels

29
Q
  • SLE
  • Scleroderma
  • Sjogren Syndrome
  • Dermatomyositis/ Polymyositis
A

Mild elevation of CRP levels

30
Q
  • Helpful tool in determining the response to antibiotic therapy and duration of treatment
A

Normalization of CRP levels

31
Q
  • Elevated levels were seen in majority of kidney or heart transplant
  • Highly elevated GVHD
A

Transplant

32
Q
  • An increase is associated with a poorer short term prognosis
A

Cerebral vein or sinus thrombosis

33
Q

________ with platelet counts (>400,000/uL) and CRP
levels (>2.45 mg/dl) have been found to be the strongest laboratory predictors of positive temporal artery biopsy

A

Thrombocystosis

34
Q
  • Level peaks 3 days after onset of pain
  • Level of 150 mg/L distinguishes mild from sever disease
A

Pancreatitis

35
Q

More sensitive than CRP especially for cardiovascular injury

A

HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP)

36
Q

HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) NORMAL RANGE

A

Normal range: <0.3 mg/dl

37
Q

USES OF HS-CRP

A
  1. Performing risk assessment for cardiovascular disease
  2. Determine risk of hypotension
38
Q

these are pathogenic
possibilities or risk factors

A

extrinsic ligands

39
Q

these are certain molecules
that are normally found inside the body

A

intrinsic/self-ligands

IS LAB SEMIS CRP & ASO (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions