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MSK II Exam II Crossword > Crossword down > Flashcards

Crossword down Flashcards

1
Q

Broad-spectrum antimicrobial agent widely used in homes and hospitals due to efficacy on skin and oral mucosa with low irritability

A

Chlorhexidine

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2
Q

Topical immune response modifier used to treat actinic keratosis and basal or squamous cell carcinomas
Also used to treat genital warts

A

Imiquimod

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3
Q

Delayed hypersensitivity reaction that can be caused by substances such as latex and drugs such as neomycin and bacitracin
Sometimes induced as treatment of skin disorders (e.g. psoriasis, alopecia)

A

Contact dermatitis

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4
Q

Aminoglycoside antibiotic of Neosporin with activity against gram-negative bacteria

A

Neomycin

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5
Q

Can be administered systemically to treat tinea capitis (ringworm in scalp)

A

Griseofulvin

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6
Q

~50% water and 50% oil with an emulsifier

Base that is useful for covering large and/or wet areas with a drug but preservatives, etc. can cause allergic reactions

A

Creams

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7
Q

Retinoid administered orally for treatment of severe acne

Powerful teratogen that mandates participation by young females in the iPledge program

A

Isotretinoin

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8
Q

Very important component of skin care for health care providers

A

Moisturizers

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9
Q

Orally active phosphodiesterase type IV inhibitor that inhibits numerous pro-inflammatory mediators
Used to moderate-to-severe plaque psoriasis and psoriatic arthritis
Severe diarrhea is an adverse effect

A

Apremilast

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10
Q

κ-opioid receptor agonist/μ-opioid receptor antagonist administered intranasally to treat intractable/nocturnal pruritus

A

Butorphanol

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11
Q

Organophosphate anticholinesterase insecticide, kills ectoparasites

A

Malathion

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12
Q 
Drug class useful for systemic treatment of acne, photosensitivity, and GI distress
Contraindication in pregnancy and young children due to gray discoloration of permanent teeth are noteworthy side effects
A

Tetracycline

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13
Q

Treatment for actinic keratosis derived from Euphorbia peplus sap
Causes chemoablation with neutrophil-mediated antibody depended cellular cytotoxicity eliminating remaining tumor cells

A

Ingenolmebutate

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14
Q

Titanium dioxide is an example that could be applied, for example, to your nose when on the beach

A

Sunshade

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15
Q

Tetracycline used to treat acne

Noteworthy for its ability to cause dark pigmentation in skin and sclera

A

Minocycline

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16
Q

Local vasoconstriction due to blood volume deficit, unrelieved pain, hypothermia, etc.
Can impair wound healing due to an inadequate amount of this in tissue

A

Oxygenation

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17
Q

Form on surfaces

Very hard to kill because resident microbes of different species help each other survive

A

Biofilms

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18
Q

Effective topical therapy for actinic keratosis
Causes fast-proliferating dysplastic cells to die a thymidine-less death
Necrosis/erosion gives way to re-epithelialization over several weeks

A

5-fluorouracil

19
Q

Substance P antagonist used to treat nausea and vomiting of chemotherapy
Also useful to treat intense itching and cutaneous T-cell lymphomas (Sezary syndrome)

A

Aprepitant

20
Q

Orally administered insecticide to treat ectoparasites

Binds glutamate-activated Cl- channels to hyperpolarization the nerve and muscle cells

A

Ivermectin

21
Q

Comprised of ~20% water and 80% oils
Best for dry skin
Stay on the surface of skin and are not well absorbed
Permit more complete drug absorption and less likely to cause allergic reaction in skin since there are no preservatives

A

Ointments

22
Q

Itching here is far less funny that it sounds

Topical calcineurin inhibitors such as tacrolimus can help treat

A

Anogenital

23
Q

Agents such as iodine, chlorhexidine, and hydrogen peroxide potentially do this to wound healing

A

Impede

24
Q

Drug class that may (e.g. for urticaria) or may not stop the itch, but the associated drowsiness may help one deal with it

A

Antihistamines

25
Q

Refers to agents such as glycerin, lecithin, and propylene glycol found in moisturizers to draw water into the outer layer of skin

A

Humectants

26
Q

When used to treat thrush, it is held in the mouth before stalling (negligible GI absorption)

A

Nystatin

27
Q

Antifungal applied topically that penetrates into nails to react fungal infection

A

Efinaconazole

28
Q

Anti-inflammatory agent known since ancient times
Keratolytic effects due to its ability to dissolve intercellular cement makes it useful for treatment of acne, dandruff, and calluses

A

Salicylic acid

29
Q

To heal best, wounds should be kept clean and _____

A

Moist

30
Q

Class of antifungal drugs with a wide range of activity

Blocks ergosterol synthesis

A

Imidazoles

31
Q

Biological DMARDs administered systemically to treat other autoimmune diseases such as psoriasis

A

TNFα blockers

32
Q

Topical therapy for treating herpes labialis (also used systemically for herpes infections at other sites)

A

Acyclovir

33
Q

Treatment for alopecia

Contract allergen applied to cause dermatitis which can be followed by hair growth

A

DPCP

34
Q

Imidazole antifungal drug applied topically for range of fungal infections
Also noteworthy as a classic inhibitor of cytochrome P450

A

Ketoconazole

35
Q

Topical antimicrobial agent commonly used to treat acne

Local skin irritating and may bleach hair or clothing

A

Benzoyl peroxide

36
Q

Inhibits the mutated BRAF V600D MAP kinase found in ~60% of melanomas

A

Vemurafenib

37
Q

Has 7 potency classes for topical administration so that is is possible to taper down to the lowest dose needed to control inflammation
Administered systemically to control pain and inflammation of rheumatoid arthritis until DMARD effects manifest
Can also be injected directly into inflamed joints

A

Glucocorticoids

38
Q

An oral hedgehog signaling pathway inhibitor used to treat advanced basal cell carcinoma

A

Vismodegib

39
Q

Lower, closer to that of skin is why synthetic detergents minimize skin irritation during home skin care

A

Ph

40
Q

Radiation that may not cause erythema and sunburn but nevertheless still does contribute to skin aging and photocarcinogenesis

A

UVA

41
Q

Late choice for treating ectoparasites

Works by disrupting GABAergic transmission

A

Lindane

42
Q

Macrolide among the systemic therapies used to treat acne
Noteworthy because it is not a cytochrome P450 inhibitor
Has unusual pharmacokinetics in that it is take up in phagocytes and released by them at sites of infection

A

Azithromycin

43
Q

Blocks conversion of testosterone to the more potent androgen dihydrotestosterone
Among its uses is to treat male pattern baldness in men and second-line agent for this in women

A

Finasteride

MSK II Exam II Crossword (2 decks)

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