Crossword across Flashcards
Refers to substance in moisturizers that form an oily layer to trap water in the skin
Petrolatum, lanolin, and mineral oil are among common examples
Emollients
Peptide antibiotic with activity against gram-positive organisms and some anaerobes
Only applied topically to limit systemic toxicity, often causes contact dermatitis
Bacitracin
Can be effective treatment for acne in women
Oral contraceptives
Monoclonal antibody against IL-12 and IL-23
Biological agent used to treat psoriasis
Ustekinumab
The formation of one of these for a drug in the skin may prolong its half-life and permit 1/day dosing
Reservoir
Antiepileptic drug used to treat neuropathic pain and itching
Gabapentin
Sometimes need to resort to things such as Unna boots in the category to try to break the itch-scratch cycle
Physical interventions
PDGF that promotes cell proliferation and angiogenesis needed for diabetic ulcer repair
Must use cautiously as too much increases risk of malignancy
Becaplermin
Control that is now considered a priority for optimal wound closure
Glycemic
K+ sparing diuretic with partial agonist properties at androgen receptors that can make it useful for treating menstrual cycle-linked acne or male pattern baldness in adult women
Spironolactone
Component of plant defenses against bacteria
Active against P. acne
Azaleicacid
Example of a systemic imidazole therapy to treat tinea versicolor
Fluconazole
Photosensitizer administered in conjunction with UVA treatment of psoriasis
Psoralen
FDA-approved conventional therapy for melanoma
Dacarbazine
Prototypical non-steroid androgen antagonist
Uses besides prostate cancer include treatment of male pattern baldness in women
Flutamide
Topical retinoids administered for the treatment of acne, alters gene expression to normalize keratinization, decrease keratinocytes cohesiveness and reduce microcomedone formation
Tretinoin
This typically happens a few days after an attack of gouty arthritis if untreated
Resolves
Can be useful therapies for neuropathic pruritus
Local anesthetics
Among the imidazole drugs commonly used to treat vulvovaginal candidiasis
Miconazole
Among OTC drugs (e.g. Tinactin) used to treat jock itch and athlete’s foot
Like terbinafine, inactive against yeasts
Tolnaftate
Cyclosporine and tacrolimus are among these agents that revolutionized transplantation therapy (didn’t cause bone marrow suppression)
Among other uses includes topical or systemic administration for psoriasis and topical administration for anogenital pruritus
Calcineurin inhibitor
Active ingredient of vulvovaginal medications for candidiasis
Clotrimazole
α2-agonist administered topically as a gel to treat rosacea
Brimonidine
Urea, alpha-hydroxyl acids, and allantoin are among the agents found in moisturizers to soften this and give skin a smoother feeling
Horny substance
Important component of wound healing
Conserves local resources by limiting need to synthesize proteases
Stage when hydrogels are good wound covering
Debridement
α-adrenergic agonist in Visine known for its ability to “get the red out”
Tetrahydrozoline
Peptide antibiotic with efficacy against gram-negative bacteria including pseudomonas
Has a detergent-like effect that damages the bacterial cell membrane
Polymixin B
Prescription synthetic topical antimycotic agent with broad spectrum of activity against fungal skin infections such as ringworm, athlete’s foot, tines versicolor, and dandruff
Ciclopirox
Class of adrenergic agonists administered topically to treat rosacea or red eyes
Alpha
Common cause of diarrhea due to antibiotic-associated colitis
Well-known example where handwashing with soap and water is superior to alcohol-based gels
C. difficile
Type of dressing useful for the granulation stage of wound repair
Foam
Antibiotic that works similar to macrolides, kills anaerobes, useful for range of infections including topical treatment of acne and for osteomyelitis
Associated with increased risk of C. difficile
Clindamycin
Synthetic insecticide similar to that of chrysanthemums, ectoparasite therapy (Nix) that binds to insect Na+ channels and prevents membrane repolarization
Permethrin
Blocks enzyme needed for ergosterol synthesis
Useful topically for fungal infections such as jock itch and athlete’s foot and systemically for fungal nail infections
Terbinafine
μ-opioid receptor antagonist that can treat the pruritus associated with chronic kidney disease and cholestasis
Naltrexone
Antifungal agent with topical effects limited to candida infections
May temporarily stain the skin yellow (also administered IV etc., for other fungal infections as well including aspergillosis endemic mycosis)
Amphotericin B
Macrolide antibiotic
Among uses is for topical or systemic treatment of acne
Among the well known cytochrome P450 inhibitors to remember
Erythromycin
Very old remedy for psoriasis
Works but color and smell create a challenge
Tar
Most important component of infection control
Hand hygiene
Potent vasodilator due to hyperpolarization via activation of K+ channels
Applied topically to grow hair
Minoxidil
