Crossword across

Question 1

Refers to substance in moisturizers that form an oily layer to trap water in the skin
Petrolatum, lanolin, and mineral oil are among common examples

Answer 1

Emollients

Question 2

Peptide antibiotic with activity against gram-positive organisms and some anaerobes
Only applied topically to limit systemic toxicity, often causes contact dermatitis

Answer 2

Bacitracin

Question 3

Can be effective treatment for acne in women

Answer 3

Oral contraceptives

Question 4

Monoclonal antibody against IL-12 and IL-23

Biological agent used to treat psoriasis

Answer 4

Ustekinumab

Question 5

The formation of one of these for a drug in the skin may prolong its half-life and permit 1/day dosing

Answer 5

Reservoir

Question 6

Antiepileptic drug used to treat neuropathic pain and itching

Answer 6

Gabapentin

Question 7

Sometimes need to resort to things such as Unna boots in the category to try to break the itch-scratch cycle

Answer 7

Physical interventions

Question 8

PDGF that promotes cell proliferation and angiogenesis needed for diabetic ulcer repair
Must use cautiously as too much increases risk of malignancy

Answer 8

Becaplermin

Question 9

Control that is now considered a priority for optimal wound closure

Answer 9

Glycemic

Question 10

K+ sparing diuretic with partial agonist properties at androgen receptors that can make it useful for treating menstrual cycle-linked acne or male pattern baldness in adult women

Answer 10

Spironolactone

Question 11

Component of plant defenses against bacteria

Active against P. acne

Answer 11

Azaleicacid

Question 12

Example of a systemic imidazole therapy to treat tinea versicolor

Answer 12

Fluconazole

Question 13

Photosensitizer administered in conjunction with UVA treatment of psoriasis

Answer 13

Psoralen

Question 14

FDA-approved conventional therapy for melanoma

Answer 14

Dacarbazine

Question 15

Prototypical non-steroid androgen antagonist

Uses besides prostate cancer include treatment of male pattern baldness in women

Answer 15

Flutamide

Question 16

Topical retinoids administered for the treatment of acne, alters gene expression to normalize keratinization, decrease keratinocytes cohesiveness and reduce microcomedone formation

Answer 16

Tretinoin

Question 17

This typically happens a few days after an attack of gouty arthritis if untreated

Answer 17

Resolves

Question 18

Can be useful therapies for neuropathic pruritus

Answer 18

Local anesthetics

Question 19

Among the imidazole drugs commonly used to treat vulvovaginal candidiasis

Answer 19

Miconazole

Question 20

Among OTC drugs (e.g. Tinactin) used to treat jock itch and athlete’s foot
Like terbinafine, inactive against yeasts

Answer 20

Tolnaftate

Question 21

Cyclosporine and tacrolimus are among these agents that revolutionized transplantation therapy (didn’t cause bone marrow suppression)
Among other uses includes topical or systemic administration for psoriasis and topical administration for anogenital pruritus

Answer 21

Calcineurin inhibitor

Question 22

Active ingredient of vulvovaginal medications for candidiasis

Answer 22

Clotrimazole

Question 23

α2-agonist administered topically as a gel to treat rosacea

Answer 23

Brimonidine

Question 24

Urea, alpha-hydroxyl acids, and allantoin are among the agents found in moisturizers to soften this and give skin a smoother feeling

Answer 24

Horny substance

Question 25

Important component of wound healing
Conserves local resources by limiting need to synthesize proteases
Stage when hydrogels are good wound covering

Answer 25

Debridement

Question 26

α-adrenergic agonist in Visine known for its ability to “get the red out”

Answer 26

Tetrahydrozoline

Question 27

Peptide antibiotic with efficacy against gram-negative bacteria including pseudomonas
Has a detergent-like effect that damages the bacterial cell membrane

Answer 27

Polymixin B

Question 28

Prescription synthetic topical antimycotic agent with broad spectrum of activity against fungal skin infections such as ringworm, athlete’s foot, tines versicolor, and dandruff

Answer 28

Ciclopirox

Question 29

Class of adrenergic agonists administered topically to treat rosacea or red eyes

Answer 29

Alpha

Question 30

Common cause of diarrhea due to antibiotic-associated colitis
Well-known example where handwashing with soap and water is superior to alcohol-based gels

Answer 30

C. difficile

Question 31

Type of dressing useful for the granulation stage of wound repair

Answer 31

Foam

Question 32

Antibiotic that works similar to macrolides, kills anaerobes, useful for range of infections including topical treatment of acne and for osteomyelitis
Associated with increased risk of C. difficile

Answer 32

Clindamycin

Question 33

Synthetic insecticide similar to that of chrysanthemums, ectoparasite therapy (Nix) that binds to insect Na+ channels and prevents membrane repolarization

Answer 33

Permethrin

Question 34

Blocks enzyme needed for ergosterol synthesis

Useful topically for fungal infections such as jock itch and athlete’s foot and systemically for fungal nail infections

Answer 34

Terbinafine

Question 35

μ-opioid receptor antagonist that can treat the pruritus associated with chronic kidney disease and cholestasis

Answer 35

Naltrexone

Question 36

Antifungal agent with topical effects limited to candida infections
May temporarily stain the skin yellow (also administered IV etc., for other fungal infections as well including aspergillosis endemic mycosis)

Answer 36

Amphotericin B

Question 37

Macrolide antibiotic
Among uses is for topical or systemic treatment of acne
Among the well known cytochrome P450 inhibitors to remember

Answer 37

Erythromycin

Question 38

Very old remedy for psoriasis

Works but color and smell create a challenge

Answer 38

Tar

Question 39

Most important component of infection control

Answer 39

Hand hygiene

Question 40

Potent vasodilator due to hyperpolarization via activation of K+ channels
Applied topically to grow hair

Answer 40

Minoxidil