Crohn's Disease Flashcards
1
Q
A young man with Crohn’s disease has been having severe exacerbations of his disease over the previous year. This is despite standard medication. You decided to prescribe him Infliximab, a biologic drug. What test must be ordered before prescribing this drug?
A
Interferon gamma release assay
Reactivation of TB in an important complication of biologic therapy and an IGRA is a test for TB latency
2
Q
Symptoms
A
Abdominal Pain Diarrhoea Weight loss Anorexia Fever Growth retardation Anaemia
3
Q
Extra intestinal Manifestation
A
Metabolic Bone Disease Aphthous Ulceration Pyoderma Gangrenosum Erythema nodosum Scleritis Episcleritis Anterior Uveitis
4
Q
Investigations
A
U: B: FBC, LFT, CRP, B12, Folate, vitamins E: I: US, endoscopy, barium S:
5
Q
Gold standard
A
Endoscopy
6
Q
Pathology
A
Skip Lesions
All through the GI tract
Transmural inflammation
Early lesions: aphthous ulcers overlying lymphoid aggregates
