Crohn's Flashcards

1
Q

what part of the GI tract can Crohn’s effect?

A

the entire GI tract

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2
Q

What is meant by Crohn’s being transmural?

A

it affect the entire thickness of the mucosa

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3
Q

the most common site of the involvement is the distal ileum, therefore pain may be mistaken for

A

appendicitis

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4
Q

what is the least common site for Crohn’s

A

the mouth and the upper GI tract, a small number will experience this as a part of the disease

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5
Q

what are apthous ulcers?

A

canker sores that may present with Crohn’s

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6
Q

1/3 of Crohn’s patient have and associated perianal disease, what may this present as

A

fistula, fissure, abscess this may be seen on rectal exam along with skin tags
therefore screen those with anal abscesses for Crohn’s

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7
Q

a patient with Crohn’s will complain of what type of pain?

A

a cramping colicky abdominal pain likely in RLQ

a palpable RLQ fullness/mass may be present

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8
Q

how do symptoms develop in patient with Crohn’s?

A

symptoms will develop gradually onset and usually be intermittent with periods of exacerbations & relative remission

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9
Q

which severity of Crohn’s involves only inflammation and strictures?

A

moderate

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10
Q

which severity of Crohn’s involves inflammation, strictures, and fistulae?

A

severe

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11
Q

what symptom is common regardless of of severity in Crohn’s?

A

inflammation

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12
Q

nocturnal diarrhea helps distinguish Crohn’s from what condition?

A

IBS, but up to 10% of those with Crohn’s may not have nocturnal diarrhea

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13
Q

are low grade fever and weight loss often present or not in Crohn’s patients?

A

they are often present

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14
Q

what type of lesion are common in Crohn’?

A

skip lesions, disease free areas between diseased part

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15
Q

string sign is often seen in patients with Crohn’s due to what?

A

inflammation

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16
Q

Arthralgias and arthritis are common in Crohn’s in which joints? and how do they present?

A
large joints (hips, knees) 
present with stiffness in the morning and gets better with activity
17
Q

other clinical presentations with Crohn’s?

A

Erythema nodosum
Eye conditions
Gallstones
Possible sclerosing cholangitis

18
Q

why are gallstones related to Crohn’s?

A

related to bile acid malabsorption in the small intestine

19
Q

most common extra-intestinal manifestation of Crohn’s?

A

Arthralgias and arthritis

20
Q

what skin condition may be present with Crohn’s?

A

jaundice

21
Q

a patient present with anemia Janice and weight loss what may you screen for?

A

Crohn’s, however it is every difficult to diagnosis if it is a patients first exacerbation

22
Q

why might a biopsy not work for a first exacerbation of Crohn’s?

A

there must be time for inflammation changes

23
Q

the colonoscopy may reach why part of the colon to diagnosis possible Crohn’s

A

terminal ileum

24
Q

after years of Crohn’s conditions what may develop and present on colonoscopy and biopsy?

A

granulomas in about 30% of patients

25
Q

what may be seen on colonoscopy of a patient with Crohn’s?

A

ulcerations, cobblestoning and possible fistulas

26
Q

CT scan of abdomen and pelvis with contrast may show what in Crohn’s patients?

A

Presence of inflammation (thickened walls), abscess, fistulas

27
Q

a string sign may be seen on

A

a small bowel follow through

28
Q

complications of Crohn’s

A

Fistula, abscess
Obstruction due to inflammation
Perforation from abscess
Nutrient deficiencies (Fe, B12)due to malabsorption in small intestine

29
Q

what 2 things may make Crohn’s worse?

A

NSAIDs and Smoking

30
Q

Crohn’s treatment approach

A

step-up

31
Q

what may be used for Crohn flares

A

antibiotics, budesonide and prednisone

32
Q

Crohn’s treatment options

A

5-ASA agents
Immunomodulators
Biologics / TNF blockers such as adalimumab