Crocker

Question 1

What is the effect of oubain?

Answer 1

Inhibition of Na+/K+ ATPase

Question 2

What is the channel that glucose or galactose for entry into the cell? What ion is used as the facilitator? What is the ratio?

What does glucose need to exit the cell?

Answer 2

It needs SGLT1. Sodium is the ion needed. 2 sodium for every glucose or galactose

It needs GLUT2

Question 3

What occurs in the deficiency of SGLT1?

Answer 3

Terminal diarrhea

Question 4

What is steatorrhea?

Answer 4

The excretion of abnormal quantities of fat with the feces owing to reduced absorption of fat by the intestine

Question 5

What is hypersecreted and hyposecreted in cystic fibrosis?

Answer 5

Hypersecretion of mucus and hyposecretion of lipases

Question 6

How is vitamin A (retinol) ingested? Vitamins D and E?

Answer 6

It is ingested as a precursor B-carotene, it is cleaved in the enterocyte

Vitamins D and E are consumed as esters

Question 7

How is cobalamin absorbed? How is it released from the ileum to the interstitial space?

Answer 7

Cobalamin is dissociated from food by pepsin and acidic pH, binds to R protein travels down to the intestine. CBL-R-protein complex is broken down by pancreatic proteases, intrinsic factor binds CBL. CBL-IF is absorbed by ileal enterocyte

To be transported out, CBL needs transcobalamin II in order to enter the interstitial space

Question 8

Where does K+ absorption occur? Secretion?

Answer 8

Absorption occurs in the small intestine INWARD K+ gradient created by high relative concentrations of dietary K+ and from secreted K+

K+ secretion occurs in the colon – basolateral Na/K ATPase establishes high intracellular [K+]