Critical events Flashcards
Anaphylaxis (what, signs, differential, management
Anaphylaxis is a type 1 hypersensitivity reaction. The antigen/drug binds to IgE on mast cells causing them to degranulate and release histamines, prostagladins and leukotrienes. This causes vasodilation, increase vessel permeability and smooth muscle contaction -> bronchospasm
Clinical signs are variable but ususally involved:
- CVS - hypotension, tachycardiac
- RESP - wheeze/bronchospasm & pulmonary oedema
- SKIN - oedema/rash
Management:
- Declare anaesthetic emergency and ask for help
- Stop giving likely drug
- Secure airway and give 100% oxygen
- IV/IM adrenaline
- IV crystalloid
- Assess response
Ongoing management:
- 10mg chlorphenamine 200mg Hydrocortisone
- Ongoing vasopressors & consider bicarbonate
- At 1 hour take mast cell tryptase
- Check for cuff leak prior to extubation
- HDU/ITU
Later management:
- refer to local allergy clinic
- yellow card
- document clearly and tell patient
Aspiration
x
Awareness
x
Blood transfusion error
x
Bradycardia
x
Cyanosis
x
Difficulty ventilating/high airway pressures
x
Failed intubation (general patient)
x
Failed intubation (obstetric patient)
x
Failure to breath post general anaesthetic
x
High spinal block
x
Hypertension
x
Hypotension
x
Hypoxia
x
Intra-arterial injection
x