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S3 Case 3 - Musculoskeletal > Creams > Flashcards

Creams Flashcards

1
Q

What is a cream?

A

Semi-solid emulsion (O/W) or (W/O)

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2
Q

What are the characteristics of a hydrophilic cream (O/W)?

A

Non-greasy
Miscible with skin secretions
H2O-washable
Non-occlusive

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3
Q

What are the characteristics of a lipophilic cream (W/O)?

A

Somewhat greasy
Less miscible with skin secretions than O/W
Less H2O-washable
Somewhat occlusive

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4
Q

What are the basic components of a cream?

A

Drug
Continuous phase
Dispersed phase
Emulsifier

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5
Q

What may it also contain?

A

Co-solvent
Thickener
Preservative
Penetration enhancer
pH regulator
Antioxidant

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6
Q

What does a co-solvent do?

A

Enhances solubility

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7
Q

What does a thickener do?

A

Enhances viscosity/stability/release profile

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8
Q

What does a preservative do?

A

Prevents microbial spoilage

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9
Q

What does a penetration enhancer do?

A

Enhances drug penetration

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10
Q

What does a pH regulator do?

A

Adjusts pH, reduces irritation

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11
Q

What does an antioxidant do?

A

Prevents oxidation degradation

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12
Q

What must happen to ensure sufficient dose + even dispersion?

A

Good solubility in either phase

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13
Q

What must happen to ensure stable emulsion?

A

Choice of suitable emulsifiers
Hydrophile-lipophile balance (HLB) + Bancroft’s rule

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14
Q

What is Bancroft’s rule?

A

High HLB emulsifier = O/W emulsion
Low HLB emulsifier = W/O emulsion

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15
Q

What is HBL?

A

Hydrophilic emulsifier = high >10
Lipophilic emulsifier = low <10

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16
Q

What is HBL matching?

A

Different oils have different HBL requirements for O/W + W/O emulsions

17
Q

How do you do HBL matching?

A

Match requirement to emulsifier HLB
Use emulsifier blends
Most stable contain single emulsifier

18
Q

How do you prepare a cream?

A

Dissolve lipophilic ingredients in oily phase, heat at minimum temp required
Dissolve hydrophilic ingredients in, aqueous phase, heat to same temp as oily
Mix both at same temp
Stir until thick emulsion
Incorporate solids by trituration

19
Q
A

S3 Case 3 - Musculoskeletal (14 decks)

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