CRC Syndromes

Question 1

FAP genetic damage

Answer 1

Loss of APC tumor-supressor, 5q (2-hit hypothesis)

Question 2

Lynch Syndrome genetic damage

Answer 2

Mismatch Repair Genes->Microsatellite Instability

Question 3

Osseous & Soft Tissue Tumors are pathognomonic for…

Answer 3

…Gardner Synrome (FAP + bones + soft tissue)

Question 4

CNS Tumors are pathognomonic for…

Answer 4

…Turcot Syndrome (FAP/Lynch +medulloblastoma/glioma)

Question 5

Hamartomas throughout the GI are pathognomonic for…

Answer 5

…No Syndrome!

Question 6

Hamartomas AND Hyperpigmentation are pathognomonic for…

Answer 6

…Peutz-Jeghers Syndrome

Question 7

Hamartomas without Hyperpigmentation instead lead our thought to…

Answer 7

Juvenile Polyposis Syndrome

Question 8

What is the mode of inheritance of ALL polyposis syndromes?

Answer 8

Autosomal Dominant

Question 9

Which of these syndromes increase RR for other GI cancer than CRC?

Answer 9

Peutz-Jehgers

Question 10

Which of these syndromes increase RR for cancer OUTSIDE the GI tract?

Answer 10

Gardner (bone & soft tissue), Turcot (CNS), Peutz-Jehgers (breast), Lynch (endometrium, ovary, skin cancer)

Question 11

Which of these syndromes increases RR for endometrium & ovary cancers?

Answer 11

Lynch Syndrome

Question 12

Which of these syndromes increases RR for skin cancer?

Answer 12

Lynch Syndrome

Question 13

Which of these syndromes increases RR for gynecological cancer?

Answer 13

Lynch Syndrome AND Peutz-Jehgers