Cranial Nerves - IX, X, XI & XII Flashcards
Where does the glossopharyngeal nerve leave the brainstem?
Where are its cell bodies located?
- it leaves the brainstem at the level of the cerebellopontine angle
- it passes lateral to the olive and inferior to the cerebellar peduncle
- some cell bodies are locard within the superior ganglion of IX and some are located within the inferior ganglion of IX
What are the 5 nuclei associated with IX and what fibre type do they receive?
SVA fibres:
- associated with the rostral solitary nucleus
GVE fibres:
- associated with the inferior salivatory nucleus
GVA fibres:
- associated with the caudal solitary nucleus
SVE fibres:
- associated with the rostral nucleus ambiguus
GSA fibres:
- associated with the trigeminal sensory nucleus
Where does the vagus nerve leave the brainstem?
Where are the cell bodies found?
- leaves the brainstem just inferiorly to IX and is made up of many different rootlets
- cell bodies are found in the superior ganglion of X and the inferior ganglion of X
What are the 5 nuclei associated with the vagus nerve and what fibre type do they receive?
SVE fibres:
- associated with the caudal nucleus ambiguus
SVA fibres:
- associated with the rostral solitary nucleus
GVE fibres:
- associated with the dorsal motor nucleus of X
GVA fibres:
- associated with the caudal solitary nucleus
GSA fibres:
- associated with the trigeminal sensory nucleus
What is the role of the nucleus ambiguus and which nerves is it associated with?
- the nucleus ambiguus has roles in speech and swallowing
- it is associated with IX and X
Describe the pathway of the UMN and LMNs associated with the nucleus ambiguus
UMN:
- travels from the motor cortex and through the corticobulbar tract of the internal capsule
- sends bilateral projections to both the superior (rostral) and inferior (caudal) poles of both nuclei ambiguus
- UMN synapses with LMN within the relevant pole of the nucleus ambiguus
LMN from superior pole of nucleus ambiguus:
- SVE fibres travel in IX to innervate stylopharyngeus
LMN from inferior pole of nucleus ambiguus:
- SVE fibres travel in X to innervate the palatine muscles, pharyngeal constrictors and intrinsic muscles of the larynx
What would happen if there was a lesion to the UMN or the nucleus ambiguus involved in speech / swallowing?
there would be no significant defect
- this pathway is served bilaterally, so a neurone from the opposite side of the brain would still send projections to the superior and inferior poles of the nucleus ambiguus on both sides
What would happen if there was a lesion to the vagus nerve (LMN) travelling from the inferior pole of the nucleus ambiguus to the relevant muscles?
- SVE fibres would not be able to reach the muscles that X usually supplies, resulting in:
- atrophy & paralysis of the palatine muscles
- nasal speech due to paralysis
- deviation of the uvula away from the lesion
- problems with speech and swallowing
Why does the uvula deviate AWAY from the lesion when there is a vagus nerve lesion?
- usually the palatine arches will elevate symmetrically
- if there is a lesion on the left side, the left levator veli palatini muscle is not working effectively
- the left palatine arch is unable to elevate, causing the uvula to deviate towards the right
- Uvula deviation is a sign of a vagus nerve lesion*
Right uvula deviation suggests left vagus nerve lesion, and vice versa
What is the pathway involved in sending parasympathetic neurones to thoracic and abdominal viscera?
UMN:
- hypothalamus sends an UMN to the dorsal motor nucleus of X
- the UMN synapses with the pre-ganglionic GVE fibres within the dorsal motor nucleus of X
LMN:
- preganglionic GVE fibres travel in X to specific ganglia located near the target organ
- the postganglionic fibres will innervate thoracic and abdominal viscera
- these GVE fibres are parasympathetic so are associated with “rest and digest” functions
What is the vagal trigone and where can it be found?
- it is a bulge located on the dorsal aspect of the brainstem
- it is found in the floor of the IVth ventricle
- it is caused by the presence of cell bodies of the dorsal motor nucleus of X and the nucleus ambiguus
- the bulge is mainly due to the presence of cell bodies within the dorsal motor nucleus
How is the solitary nucleus divided and what fibre types are received by each division?
Caudal solitary nucleus:
- receives GVA fibres associated with the condition of internal organs (IX, X)
Rostral solitary nucleus:
- receives SVA fibres associated with taste (VII, IX, X)
Where do IX and X carry GVA fibres from to reach the caudal nucleus solitaris?
IX carries GVA fibres from:
- baroreceptors in the carotid sinus
- chemoreceptors in the carotid body
X carries GVA fibres from:
- mucosa of the pharynx, larynx, soft palate & thoracic / abdominal viscera
- baroreceptors in the aortic arch
- chemoreceptors in the aortic arch
How does viscerosensory information carried by IX reach the brain?
Where does this information come from?
- baroreceptors in the carotid sinus monitor changes in blood pressure
- chemoreceptors in the carotid body monitor blood composition (including levels of O2 and CO2
- baroreceptors and chemoreceptors send GVA fibres via IX
- cell bodies are located in the inferior ganglion of IX
- the central processes of IX reach the brainstem and descend to reach the caudal solitary nucleus via the solitary tract
- from the caudal solitary nucleus, a second order neurone projects to the hypothalamus
How does viscerosensory information carried by X reach the brain?
Where does this information come from?
- X carries GVA fibres carrying sensory information from:
- pharynx / larynx
- thoracic / abdominal viscera
- information about blood pressure / chemistry at the level of the aortic arch
- cell bodies are located in the inferior ganglion of X
- central process of X reaches the brainstem and descends within the solitary tract to reach the caudal solitary nucleus
- ascending projections travel from the caudal solitary nucleus to the hypothalamus to inform it about the current state of the viscera