Cranial Nerves Flashcards
Where are cranial nerve nuclei located?
In tegmentum portion of brain stem in between dorsal and ventral portions
What nuclei are present in midbrain
CN III, IV
What nuclei are present in pons?
CN V, VI, VII, VIII
What nuclei are present in the medulla?
CN IX, X, XII
What nuclei are present in the spinal cord?
CN XI
What is the afferent an efferent stimulus for corneal reflex?
CN V1 is afferent (nasociliary branch) and CN VII (temporal branch: orbicularis oculi) is efferent branch
What is the afferent and efferent stimulus for lacrimal reflex?
CN V1 is afferent and CN VIII is efferent
What is the afferent and efferent for jaw jerk reflex?
CN V3 (sensory) is afferent and V3 (motor-masseter) is efferent
Afferent and efferent for pupillary reflex?
CN II-afferent
CN III-efferent
Afferent and efferent for gag reflex?
CN IX-afferent
CN X-efferent
What vagal nuclei is involved in receiving visceral sensory information (taste, baroreceptors, and gut distention) and includes CN VII, IX, X?
Nucleus Solitarius
What vagal nerve nuclei is involved in motor innervation of pharynx, larynx, and upper esophagus (swallowing, palate elevation) from IX, X, XI (cranial portion)?
Nucleus ambiguus
What vagal nerve nuclei sends autonomic fibers to heart , lungs, and upper GI from CN X?
Dorsal motor nucleus
Which cranial nerves go through cribriform plate, middle cranial fossa, and posterior cranial fossa?
CNI
CN II-VI through sphenoid bone
CN VII-XII through temporal or occipital bone
What runs through optic canal?
CN II, ophthalmic artery, and retinal vein
What runs through superior orbital fissure?
CN III, IV, V1, VI, opthalmic artery, sympathetic fibers
What runs through foramen rotundum?
CN V2,
What runs through foramen ovale?
CN V3
What runs through foramen spinosum?
Middle meningeal artery
What runs through internal auditory meatus?
CN VII, VIII
What runs through jugular foramen?
CN IX, X, XI, jugular vein
What runs through hypoglossal canal?
CN XII
What runs through foramen magnum?
Spinal roots of CN XI, brain stem, and vertebral arteries
CN V Motor lesion?
Jaw deviates toward side of lesion due to unopposed force from opposite pterygoid muscle
CN X lesion?
uvula deviates away from side of lesion
CN XI lesion?
shoulder droop and and turning head to contralateral side of lesion
CN XII lesion?
tongue deviates toward side of lesion (“lick your wounds)” and decreased tongue muscles on affected side.
What 3 muscles are used to close the jaw and what are they innervated by?
Masseter, teMporalis, Medial pteryoid. V3
Describe pathway of pupillary light reflex
1) Signal via CN II to pretectal nuclei (in midbrain)
2) Activates Edinger-Westphal nuclei
3) Pupils contract bilaterally via CN II output to ciliary ganglion and short ciliary nerves to pupillary sphincter muscles
Early onset alzheimers
Late onset
Earl onset: APP (Chr 21), presinilin 1 (Chr 14), presinilin 2 (Chr 1)
Late onset: ApoE4 (Chr 19), ApoE2 (Chr 19) is protectivve
Associated with JC virus. CNS destruction of oligodendrocytes with increased risk associated with natlizumab
Progressive multifocal leukoencephalopathy
Multifocal perivenular inflammation and demyelination after infection (commonly measles or VZV) or certain vaccinations (Rabies/smallpox)
Acute disseminated (postinfections) encephalomyelitis
Autosomal recessive. Arylsulfatase A deficiency and buildup of myelin–>central and peripheral demyelination with ataxia, dementia
Metachromatic leukodystrophy
Auto rec. lysosomal storage disease with deficiency in galactocerebrosidase–>myelin sheath destruction. Peripheral neuroapthy, developmental delay
Krabbe disease
X-linked genetic affecting males disrupting metabolism of very long chain fatty acids–>excessive nervous system buildup, adrenal gland, and testes affected.
Adrenoleukodystrophy
Seizures casue by age
1) Children
2) Adults
3) Elderly
1) Genetic, infection (febrile), trauma, congenital metabolic
2) Tumor, Trauma, Stroke, Infection
3) Stroke, tumor, trauma, infection
What is the vestibular pathway?
Hair of labyrinth structures–>vestibular ganglion–>vestibular nuclei in brainstem–>cerebellum, MLF, spinal cord, thalamus