CPGs Flashcards
Adrenaline Pharmacology
Alpha- and beta-adrenergic agonists
Beta 1: Increases HR, increases conduction velocity through AV node, increases myocardial contractility and increases irritability of the ventricles
Beta 2: Causes bronchodilatation
Alpha: Causes peripheral vasoconstriction
Contraindications and Precautions Adrenaline
Contra: Hypovolamic shock without adequate fluid replacement
Precaution: Elderly patients, pts with cardiovascular disease, pts on monoamine oxidase inhibitors, if pt beta blocked higher dosage may be required
Metabolism + Excretion of Adrenaline
By monoamine oxidase and other enzymes in the blood, in the liver and around nerve endings, and is excreted by the kidneys
Side Effects Adrenaline
Sinus tachycardia, supra-ventricular arrhythmia’s, ventricular arrhythmia’s, hypertension, papillary dilatation, may increase size of MI, anxiety / palpitations, muscle tremour
Aspirin Pharmacology
An analgesic, antipyretic, anti inflammatory and anti plate agent - which reduces platelet aggregation and inhibits synthesis of prostaglandins which has anti inflammatory actions
Metabolism and Excretion Aspirin
Converted to salicylate in the gut mucosa and liver, excreted mainly by the kidneys
Contraindications and Precautions Aspirin
Contras: hypersensitivity to aspirin / salicylates, actively bleeding peptic ulcer, bleeding disorders, suspected dissecting AAA, chest pain associated with psychostimulant overdose of BP >160
Precautions: peptic ulcer, asthma, on anticoagulants
Side effects aspirin
Heartburn, nausea, GI bleeding, increased bleeding times, hypersensitivity reactions
Why is aspirin contraindicated for use in active febrile illness for those under 12 years old?
It may lead to renal function impairment and Reye’s syndrome
Ceftriaxone Pharmacology
Cephalosporin Antibiotic
Ceftriaxone Metabolism and excretion
Excreted unchanged in urine and in bile
Contraindications Ceftriaxone and Precautions
Contra: Allergy to cephalosporin antibiotics
Precaution: Allergy to penicillin antibiotics
Side effects Ceftriaxone
Nausea and vomiting, skin rash
What alterations are made to ceftriaxone IM and IV administration?
IV: make up to 10ml per 1g and administer over 2 minutes
IM: Make up to 4ml per 1G and must be administered to lateral upper thigh.
Dexamethosone Pharmacology
A corticosteroid secreted by the adrenal cortex, it relieves inflammatory reactions and provide immunosuppresion.
Metabolism and excretion Dexamethasone
Metabolised by the liver and excreted predominantly by the kidneys
Contraindications and Precautions of dexamethasone
Contra: known hypersensitivity to dexamethasone or other corticosteroids
Precautions: usually only relevant with prolonged use and high dosages
Side effects Dexamethasone:
Except for allergens. adverse effects are usually only associated with prolonged use and high dosages
Diazapam Pharmacology
Member of the benzodiazapam family, inhibits anxiolytic, muscle relaxant and sedative effects. muscle- relaxant, a Most of these effects are thought to result from a facilitation of the action of GABA (The allosteric binding increases the frequency at which the chloride channel opens, leading to an increased conductance of chloride ions. This shift in charge leads to a hyperpolarization of the neuronal membrane and reduced neuronal excitability)
Metabolism / Excretion diazepam
Diazepam is metabolized in the liver to its active metabolite which is excreted in the urine as inactive metabolite
Contraindication / Precautions Diazepam
Contra: Known allergy to benzodiazapines and myasthenia gravis
Precaution: CNS depression or ingestion of CNS depressing agents, hypotension,
children and elderly, impaired renal or hepatic function, respiratory insufficiency
Define Myasthenia gravis
A chronic autoimmune, neuromuscular disease that causes weakness in the skeletal muscles
Side effects diazepam
Extrapyramidal reactions, drowziness, bradycardia, respiratory depression, hypotension
What are extra pyramidal reactions?
Drug-induced movement disorders aincluding dystonia, akathisia, and parkinsonism.
Droperidol Pharmacology
Antipsychotic - inhibits dopamine mediated neurotransmission in the cerebrum and basal ganglia, also inhibits the chemoreceptor trigger zone in the medulla
Contraindications / Precautions Droperidol
Contras: Known allergy, parkinsons disease, previous dystonic reaction to droperidol, patients under 8 years old
Precautions: Concomitant use of CNS depressants
Metabolism / Excretion Droperidol
Hepatic metabolism with bilary / renal excretion as inactive metabolites
Side effects Droperidol
Extrapyramidal reactions,
Fentanyl Pharmacology
A synthetic narcotic analgesic. IT binds to opioid receptors, especially the mu opioid receptor, which are coupled to G-proteins. Activation of opioid receptors causes GTP to be exchanged for GDP on the G-proteins which in turn down regulates adenylate cyclase, reducing concentrations of cAMP. Reduced cAMP decreases cAMP dependant influx of calcium ions into the cell. The exchange of GTP for GDP results in hyperpolarization of the cell and inhibition of nerve activity. Decreased conduction velocity of AV node
Side effects Fentanyl
Sedation, respiratory depression, apnoea, rigidity of diaphragm and intercostal muscles, bradycardia
Fentanyl metabolism / excretion
Metabolised by the liver and excreted by the kidneys
Contras / Precautions Fentanyl
Contras: Known hypersensitivity, active labour, epistaxis or occluded nasal passages (IN admin), Patients <1 years olf
Precautions: Eldery Patients, resp depression (eg COPD), current asthma, known addiction to narcotics, Monoamine Oxidase inhibitors
Glucagon Pharacology
A hormone normally secreted by the pancreas. Causes an increase in blood glucose concentration by converting stored liver glycogen to glucose. Has weak chronitropic and inotropic effect.
Glucagon metabolism
Metabolized by the liver, the kidneys and in the plasma.
Contras / precaution s glucagon
NIL of significance
Side effects glucagon
Nausea and vomiting
Glucose solution 10% Pharmacology
A slightly hypertonic crystalloid solution composed of 10% dextrose and 90% water
Metabolism glucose solution 10%
Glucose is broken down in most tissues, and stored in the liver and muscles as glycogen
Contras / precautions glucose 10% solution
NIL of significance
Glyceryl trinitrate GTN pharmacology
A vascular smooth muscle relaxant. Venous dilatation premotes venous pooling and reduces venous return to the heart (reduces preload). Arterial dilatation reduces systemic vascular resistance and arterial pressure (reduces afterload)
GTN metabolism
In liver
GTN contras / precautions
Contras: known hypersensitivity, Sys BP <100 for buccal, sys BP <120 for IV, Viagra, levetra in past 24 hours or cialis past 4 days, HR >150, HR <50 (excluding autonomic disreflexia, VT, right ventricular infarct
Precautions: No previous admin, elderly pts, recent AMI, inferior STEMI with sys BP <160, avoid skin contact with concentrated solution, always reduce BP slowly rather than aggressively
Side effects GTN:
Tachycardia, hypotension, headache, skin flushing, bradycardia
Ibuprofen Pharmacology
Non-selective NSAID that inhibits the synthesis of prostoglandins and COX. This results in analgesia, anti-inflammatory and antipyretic effects
Metabolism / excretion ibuprofen
Metabolised by liver and excreted by the kidneys
Contras / Precautions Ibuprofen
Contras: heart failure / cardiovascular disease, pregnancy 3rd trimester, pts taking anticoags, renal disease, current bleed GI bleeding or peptic ulcer, severe renal impairment, children <3 months
Precautions: asthma, previous hx GI bleeding or peptic ulcers, dehydration / hypolvolamia / diuretic treatment, elderly, chicken pox
Side effects ibuprofen
nausea, dyspepsia, GI bleeding, dizziness
Ipratropium bromide Pharmacology
Anticholinergic bronchodilator. Allows bronchodilation by inhibiting cholinergic bronchomotot tone (blocks vagal reflexes which mediate bronchocontriction)
Metabolism and Excretion Ipratropium Bromide
Metabolised in the GI tract, excreted by the kidneys
Contras / Precautions Ipratropium Bromide
Contras: Allergies to atropine or its derivatives
Precautions: Glaucoma, avoid contact with eyes
Side Effects Ipratropium Bromide
Headache, nausea, dry mouth, skin rash, tachycardia, palpitations, acute angle closure glaucoma secondary to direct eye contact
Lignocaine Hydrochloride Pharmacology
A local anaesthetic agent. Prevents initiation and transmission of nerve impulses causing local anaethesia
Metabolism Lignocaine Hydrochloride
Metabolised 90% liver, excreted 10% unchanged in the kidneys
Contraindications / Precautions Lignocaine
Contras: Known hypersensitivity, bradycardia with inadequate perfusion, evidence of a second or third degree heart block
Precaution: Only IM admin due to potential CNS complications
Methoxyflurane pharmacology
Inhalational analgesic agent at low concentrations. CND depressant
Methoxyflurane Contras / Precautions
Contras: Prexisting renal disease / impairment, concurrent use of tetracycline antibiotics, exceeding total dose of 6ml in 24 hours or 15 ml in seven days, family history or anesthetic induced malignant hyperthermia
Precautions: Must be handheld by pt, preeclampsia
Side Effects methoxyflurane
Drowziness, decrease in BP and HR (rare), exceeding maximum dose may lead to renal toxicity
Metoclopromide Pharmacology
Metoclopramide is an antiemetic and dopamine receptor antagonist. Accelerates gastric emptying and peristalsis
Metabolism / Excretion Metoclopromide
Metbolised by the liver and excreted by the kidneys
Contras / Precautions Metoclopromide
Contras: GIT haemorrage, obstruction or perforation, known sensitivity or intolorance, <16 years of age
Precautions: Undiagnosed abdominal pain
Side Effects metoclopromide
Drowziness, lethargy, dry mouth, muscle tremour, hypotension / Hypertension. extrapyramidal reactions, lowers the seizure threshold
Midazolam Pharmacology
CND depressant of the benzodiazapine class. Benzodiazepines enhance the inhibitory action of the amino acid neurotransmitter gamma-aminobutyric acid (GABA). Antianxiolytic, sedative and anti-convulsant properties.
Contras / Precautions Midazolam
Contras: Known hypersensitivity to benzodiazapines
Precautions: reduced dosage may be required for the elderly, chronic renal failure, CCF or shock, The CND deppressants effects are enhanced in the presence or narcotics or alcohol, can cause severe resp depression in pts with COPD, pts with mysthenia gravis
Side effects midazolam
Depressed level of consciousness, resp depression, loss of airway control, hypotension
Morphine Pharmacology
A narcotic analgesic.
Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals pain-modulating neurons in the spinal cord, and inhibits primary afferent nociceptors to the dorsal horn sensory projection cells.
Contraindications / Precautions Morphine
Contras: Known hypersensitivity, labour
Precautions: Elderly, hypotension, resp depression, current asthma, resp tract burns, known addiction to narcotics, acute alcholism, pts on monoamine oxidase inhibitors
Morphine metabolism / excretion
Metabolised by the liver and excreted by the kidneys
Morphine Side Effects
CNS effects: Drowziness, resp depression, euphoria, N+V, pin-point pupils, addiction
CV effects: Hypotension, bradycardia
Naloxone Pharmacology
A narcotic antagonist. It is a competitive inhibitor of the opioid receptor. Naloxone antagonizes the action of opioids, reversing their effects.
Metabolism Naloxone
Metabolised in the liver
Contras / Precautions Naloxone
Contras: Nil
Precautions: If pt is dependant on narcotics they may become combative after admin, neonates
When should naloxone not be administered?
Following a narcotic assoiciated cardiac arrest or following a head injury
Ondansatron Pharmacology
A seretonin 5-HT3 receptor antagonist. Effects are on both central and peripheral nerves. It reduces the activity of the vagus nerce, thereby inhibits the vomiting centre in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone
Contras / Precautions Ondansatron
Contras: Known hypersensitivity, children <2 years old
Precautions: impaired hepatic function, elderly, pregnancy, lactation
Metabolism / Excretion Ondansatron
Metabolised by liver and excreted by the kidneys
Side Effects Ondansatron
Headache, skin flusing, extrapyramidal effects, arrhythmia
Pharmacology Normal Saline
An isotonic crystalloid solution