Coughing in dogs Flashcards

1
Q

What are the main canine URT diseases?

A

Common: Post nasal drip (purulent rhinitis)
BOAS with retching of saliva, aspiration pneumonia
Laryngeal paralysis
Tracheal collapse
Kennel cough

Less common
Laryngeal neoplasia
Inflammatory laryngitis
Tracheal polyp
Oropharyngeal penetrating stick injuries
Primary ciliary dyskinesia
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2
Q

What are the common lower airway and pulmonary parenchymal diseases causing cough in the dog?

A
inhaled airway FB
Chronic bronchitis
Eosinophilic bronchopneumopathy
Bronchomalacia
Lungworm disease
Idiopathic pulmonary fibrosis
Aspiration pneumonia
Pulmonary neoplasia (primary or metastatic)
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3
Q

What are the uncommon lower airway and pulmonary parenchymal diseases causing cough in the dog?

A
Non-cardiogenic oedema
Bronchiectasis
Lung lobe torsion
Pneumocystis pneumonia
Viral pneumonia
Pulmonary granuloma (eg, eosinophilic)
Pulmonary abscess
Pulmonary haemorrhage (warfarin poisoning)
Irritant gas inhalation
Trauma
Fungal pneumonia (rare in the British Isles)
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4
Q

What cardiac diseases can cause a cough

A

Left atrial dilation causing compression of the left mainstem bronchus
Pulmonary oedema
Pericardial effusion
Heart base tumour

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5
Q

What pleural space diseases cause a cough?

A

Large mediastinal mass compressing airways
Large hilar lymph nodes compressing airways
Pleural effusions
Pleuritis

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6
Q

What oesophageal disorders can cause cough?

A

Megaoesophagus causing retching or aspiration pneumonia
Gastro-oesophageal intussusception causing
retching or leading to aspiration

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7
Q

What may a cough on excitement suggest?

A

might be suggestive of dynamic large airway collapse.

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8
Q

Why can nasal discharge lead to a cough and what can you infer from this?

A

discharge trickling to the pharynx and triggering a cough, sometimes referred to as a ‘post-nasal drip’. In the majority of these cases the nasal discharge is also evident at the nares along with other nasal signs and nasal disease can reasonably be assumed to be the cause of the cough. However, it would be prudent to obtain chest radiographs and perform bronchoscopy to screen for lower airway disease.

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9
Q

Outline BOAS syndrome

A

typically narrowed nares, overlong and/or fat soft palate, hypoplastic trachea and possibly swollen
or prolapsed laryngeal saccules. BOAS predominately
results in inspiratory stertor and inspiratory dyspnoea.
However, many dogs also tend to regurgitate or retch
dogs may have concurrent gastric irritation or even
a hiatal hernia that contributes to the saliva accumulation. In some, the saliva, or even food, can be aspirated leading to a ventral pneumonia or airway irritation, triggering coughing
Non-cardiogenic pulmonary oedema can also be triggered by acute and severe episodes of dyspnoea from the upper airway obstruction.

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10
Q

How does laryngeal paralysis present?

A

usually affects older dogs of large breeds (labrador, setter, etc) and may also present with a history of decreased exercise tolerance and coughing

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11
Q

What are the signs of laryngeal paralysis?

A

usually a change in tone of the bark (if the dog barks) and they usually have a degree of inspiratory dyspnoea with an increased and prolonged airway noise (stridor) on auscultation over the larynx/trachea. The clinical signs can be exacerbated by heat or exercising on warm days,

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12
Q

How do you diagnose laryngeal paralysis?

A
The diagnosis requires laryngoscopy (in sternal recumbency) under a very light plane of anaesthesia, such that the swallowing reflex is still present. Timing with breathing is critical to the diagnosis.
In the normal dog, there should be active abduction of
the arytenoids (opening of the glottis) during inspiration; failure to do so is indicative of paralysis
You can get paradoxical movement - inspiration pulses the arytenoids in due to pressure
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13
Q

How do you treat laryngeal paralysis?

A

surgically managed with a tie-back procedure for those in which there is a significant inspiratory dyspnoea or stridor.
Only do this in very affected dogs as there are lots of risks.
Approx 5-10% already have aspiration pneumonia at time of dx, 10-30% will get it after sx, there is always a lifelong risk of getting it

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14
Q

How does tracheal collapse present?

A

affects small breed dogs (eg, Yorkshire terrier), which present with chronic, ‘honking’ coughing exacerbated by excitement.
Caused by a dorsoventral flattening of the trachea, 4 stages progressive
25% of toy breeds have it by 1 year old
Once symptomatic there is a cough - inflammation cycle

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15
Q

How do you diagnose tracheal collapse?

Has 4 levels and severity and is progressive!

A

A radiographic diagnosis alone is often insufficient, requiring an element of luck in recording the movement of the trachea, with both inspiratory and expiratory views required. Bronchoscopy (Fig 2) and/or fluoroscopy (Fig 3) are much more useful in assessment of a moving structure such as tracheal collapse

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16
Q

How do you treat tracheal collapse?

A

Weight loss and avoidance of collars are an important
part of the medical management of the condition.

Antitiissives - codeine, atropine, butorphanol

As a salvage procedure a tracheal stent can be implanted in patients with severe
obstructive airway disease that is causing life threatening dyspnoea (this requires fluoroscopic image intensification). However, dogs will continue to cough and so cough alone is not an indication for this

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17
Q

What is bronchomalacia?

A

refers to narrowing or collapse (usually dynamic) of the principal bronchi and/or lobar bronchi associated with weakness in the airway walls. Many dogs with tracheal collapse (see above) also have bronchomalacia and this is referred to as tracheobronchomalacia (TBM).
There is a high prevalence of airway collapse
in brachycephalic breeds. TBM is often concurrently
present with lower airway diseases (described later)
and has similar clinical signs

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18
Q

How do you treat bronchomalacia?

A

The airway collapse triggers chronic and often severe coughing, which in itself triggers airway inflammation. Breaking the cycle is key to easing clinical signs by decreasing inhaled environmental irritants, providing bronchodilators and reducing inflammation with corticosteroids. Additionally, concurrent respiratory disease and obesity needs to be addressed. Cough suppressants can also be helpful in some cases to break the cough-inflammation cycle.

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19
Q

How does an airway FB present?

A

causes acute onset coughing that can mimic kennel cough. The cough can seem to abate with empirical treatment, but then leads to a localised bronchopneumonia and recurrence of the cough some weeks later, when halitosis may become a prominent clinical sign.

20
Q

How do you diagnose airway FBs?

A

progression to a lobar pneumonia would be radiographically evident. Bronchoscopy is essential in these cases, not only for visualisation of the FB but also for retrieval. In experienced hands, the vast majority of FBs can be removed with endoscopic visualisation and appropriate endoscopic instruments. Surgery would rarely be needed for this condition. Very small grass seeds will become lodged in very small airways, which an endoscope cannot reach; these can migrate through the lung tissue and into the pleural space, leading to a pyothorax, pneumothorax or an abscess in dogs

21
Q

How does chronic bronchitis present?

A

usually affects middle aged to older dogs and is defined as daily coughing of more than two months duration. In some patients, abnormal respiratory sounds can be auscultated, such as expiratory wheeze and pulmonary crackles, but in others, lung auscultation can be unremarkable. Dogs often present with an expiratory dyspnoea and end-expiratory abdominal heave.

22
Q

What do you find on ix for chronic bronchitis?

A
Radiographic abnormalities (ie, the intensity of a bronchial pattern) do not always correlate with the degree of inflammation . Bronchoscopic examination often reveals a widespread mucoid airway discharge, mucosal thickening and irregularity and narrowing of smaller bronchi 
 (BAL) is useful to assess the airway cell response and search for evidence of any infection
23
Q

How do you treat chronic bronchitis?

A

Palliative treatment is usually offered with a combination of steroids (oral and/or inhaled), bronchodilators, antibiotics, nebulisation and weight loss. Treatment is usually necessary for several weeks and many patients will require life-long treatment. Complete resolution of the cough is rare, but control to a tolerable level is the objective. Suppression of the cough with anti-tussives should be avoided, as this will result in a further accumulation of mucus within the lower airways and exacerbation of the clinical signs
Avoid dust, air fresheners, lots of other dogs
Harness not leads

24
Q

What is eosinophilic broncho-pneumopathy?

A

eosinophilic pneumonia. Eosinophilic lung disease
is not well understood, but certainly an eosinophilic
cell response can be seen with parasitic lung disease
(see later); but in the absence of that, the condition
is termed idiopathic. The severity of this condition
ranges from very mild, with minimal evidence on radiography or bronchoscopy, to severe airway changes that can mimic chronic bronchitis

25
Q

What are the clinical signs of eosinophilic bronchopneumopathy?

A

The predominant clinical sign in the vast majority of cases is a cough; however, severely affected dogs can also present with dyspnoea and exercise intolerance. Abnormal lung auscultatory findings are heard in some severe cases (eg, crackles, wheezes)

26
Q

How do you diagnose EBP?

A

Thoracic radiographs may show a generalised broncho-interstitial pattern and sometimes also
patchy or focal alveolar patterns. Occasionally, some
dogs present with an eosinophilic granuloma, which
can mimic a neoplastic mass (or nodular metastases).
The diagnosis is reached with bronchoscopy and airway cytology.

27
Q

How do you treat EBP?

A

Steroids and bronchodilators, try to find LED EOD

Must rule out parasites first

28
Q

What do you see on rads for lungworm?

A

In these cases, radiographs usually show a mixed interstitial-bronchial pattern in the caudodorsal lung fields, often with focal patches of an alveolar pattern (which is associated with haemorrhage in the lung tissue)

29
Q

How do you diagnose lungworm?

A

larvae in faeces (Baermann technique) or in BAL fluid. However, a negative finding does not rule out
the presence of lungworm infection. Real-time polymerase chain reaction (PCR) assay is now commercially available for A vasorum (but not C vulpis or O osleri). This PCR assay can be run on BAL fluid and faeces, as well as blood, lung tissue and endotracheal mucus. In suspicious cases, anthelmintic medication should be administered and the response assessed.

30
Q

How does idiopathic pulmonary fibrosis present?

A

mainly terrier type breeds, particularly West
Highland white terriers and cairn terriers. A gradual
decrease in exercise tolerance is the main complaint,
with some dogs also presenting with a chronic cough.
The most characteristic finding is marked pulmonary
crackles on auscultation, particularly in the ventral
lung fields, which may be associated with an expiratory wheeze

31
Q

How do you diagnose IPF?

A

diffuse and widespread interstitial pattern in the lungs,
although there is sometimes a degree of bronchial
markings too. There is often some degree of
right-sided cardiomegaly as well. Pulmonary hypertension can develop in chronic cases, leading to
echocardiographic findings of right ventricular
hypertrophy and pulmonary artery dilation (cor
pulmonale). CT is considered one of the most useful diagnostic tests with characteristic pulmonary

32
Q

How do you treat IPF?

A

Palliative treatment can be offered for the pulmonary hypertension and secondary inflammatory complications (steroids and bronchodilators), but there is no specific treatment

33
Q

how does aspiration pneumonia present?

A

It can be secondary to conditions such as swallowing disorders, megaoesophagus, BOAS and laryngeal paralysis. Clinical signs often associated with aspiration pneumonia can include tachypnoea and a cough that is often soft

34
Q

How do you diagnose aspiration pneumonia?

A

. The characteristic radiographic appearance is an intense or consolidated to variable alveolar pattern in the ventral lung lobes where aspirated food/saliva/material trickles down to the tracheal carina and then falls by gravity into the ventral lung lobes Bronchoscopy usually demonstrates a purulent airway discharge and BAL can be submitted for cytology and bacteriology

35
Q

How do you treat aspiration pneumonia?

A

The treatment relies primarily on antibiotics, but

additionally bronchodilators, nebulisation and coupage can help.

36
Q

How do you diagnose pulmonary haemorrhage?

A

Chest radiographs will show a widespread alveolar
pattern often throughout the lung fields (although
there may be a mild gravitating distributing to the
ventral lung lobes) that can mimic pulmonary oedema. Diagnosis is usually confirmed on blood work
(coagulation profile) when this is a differential.

37
Q

What does inspiratory noise suggest?

A

URT disease - do not expect this with anything else

URT needs structure - increase pressures promotes airway collapse (e.g. stress/ obesity)

38
Q

What is laryngeal paralysis a part of?

A

Geriatric Onset Laryngeal Paralysis Polyneuropathy (GOLPP)
laryngeal/ pharyngeal/ oesophageal/ limb issues
Overt signs noted in 50% of dogs at dx of LP

39
Q

Outline progression of tracheal collapse

A
Cough- inflammation cycle
Mucosal inflammation
squamous metaplasia
Loss of normal ciliary clearance
Increasingly viscoid mucous
40
Q

What does a loss of 10% diameter of the airway lead to ?

A

50% increase in pressure

41
Q

What are the secondary consequences of BOAS?

A

Everted laryngeal saccules
Everted tonsils
Laryngeal collapse

42
Q

BOAS sx tends to improve GI signs of brachy dogs. What else can be done for them?

A

Avoid high intragastric pressures - small meat/ soft food meals. Low fat
Avoid oesophagitis - omeprazole
Maintain lower oesophageal tone - cisapride

43
Q

What occurs in chronic bronchitis?

A

airway lumen narrowing develops from a combination of airway thickening and excessive mucus production and accumulation, which result in increased airway resistance. This resistance is especially pronounced during expiration

44
Q

What do dogs with bronchitis typically show on bronchoscopy?

A

irregular mucosal surfaces with a loss of the glistening appearance seen in healthy airways. Often the mucosa was noted as being thickened and granular with a roughened appearance. Most dogs in the same study had hyperemia of mucosal vessels and showed partial collapse of bronchi during expiration, suggesting concurrent bronchomalacia

45
Q

What would you expect to see on BAL with a chronic bronchitis patient?

A

predominantly neutrophilic infiltrate with excessive mucus

46
Q

What dose of steroids should be used with bronchitis?

A

1-2mg/kg SID initially, ideally drop after a good drop in coughing after approx 10 days. Ideally get to LED that is EOD