COUGH-TOPICAL NASAL DECONGESTANTS Flashcards

1
Q

What is the trade name of the product with the primary ingredient Oxymetazoline HCl 0.05%

A

,Afrin Original Nasal Spray

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2
Q

What is the trade name of the product with the primary ingredient Oxymetazoline HCl 0.05%

A

,Vicks Sinex Nasal Spray

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3
Q

What is the trade name of the product with the primary ingredient Phenylephrine HCl 1%

A

,4-Way Fast Acting

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4
Q

What is the trade name of the product with the primary ingredient Phenylephrine HCl 0.25%

A

,Neo-Synephrine Mild Strength Nasal Spray

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5
Q

What is the trade name of the product with the primary ingredient Phenylephrine HCl 0.125%

A

,Little Remedies Decongestant Nose Drops

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6
Q

What is the trade name of the product with the primary ingredient Xylometazoline 0.1%

A

,Otrivin Medicated Cold & Nasal Spray

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7
Q

What is the primary ingredient of Afrin Original Nasal Spray

A

,Oxymetazoline HCl 0.05%

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8
Q

What is the primary ingredient of Vicks Sinex Nasal Spray

A

,Oxymetazoline HCl 0.05%

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9
Q

What is the primary ingredient of 4-Way Fast Acting

A

,Phenylephrine HCl 1%

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10
Q

What is the primary ingredient of Neo-Synephrine Mild Strength Nasal Spray

A

,Phenylephrine HCl 0.25%

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11
Q

What is the primary ingredient of Little Remedies Decongestant Nose Drops

A

,Phenylephrine HCl 0.125%

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12
Q

What is the primary ingredient of Otrivin Medicated Cold & Nasal Spray

A

,Xylometazoline 0.1%

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13
Q

What is the recommended dosage for Ephedrine 0.5% in adults and children ≥ 12 years

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

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14
Q

What is the recommended dosage for Ephedrine 0.5% in children 6 to < 12 years

A

,1–2 drops/sprays in each nostril not more often than every 4 hours

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15
Q

What is the recommended dosage for Ephedrine 0.5% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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16
Q

What is the recommended dosage for Levmetamfetamine 0.04–0.15 mg/800 mL of air in adults

A

,2 inhalations in each nostril not more often than every 2 hours

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17
Q

What is the recommended dosage for Levmetamfetamine 0.04–0.15 mg/800 mL of air in children 6 to < 12 years

A

,1 inhalation in each nostril not more often than every 2 hours

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18
Q

What is the recommended dosage for Levmetamfetamine 0.04–0.15 mg/800 mL of air in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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19
Q

What is the recommended dosage for Naphazoline 0.05% in adults

A

,1–2 drops/sprays in each nostril not more often than every 6 hours

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20
Q

What is the recommended dosage for Naphazoline 0.05% in children 6 to < 12 years

A

,Not recommended for children <12 years except under advice of HCP

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21
Q

What is the recommended dosage for Naphazoline 0.05% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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22
Q

What is the recommended dosage for Oxymetazoline 0.05% in adults and children ≥ 12 years

A

,2–3 drops/sprays in each nostril not more often than every 10–12 hours (maximum: 2 doses/ 24 hours)

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23
Q

What is the recommended dosage for Oxymetazoline 0.05% in children 6 to < 12 years

A

,2–3 drops/sprays in each nostril not more often than every 10–12 hours (maximum: 2 doses/ 24 hours)

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24
Q

What is the recommended dosage for Oxymetazoline 0.05% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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25
Q

What is the recommended dosage for Phenylephrine 1.0% in adults

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

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26
Q

What is the recommended dosage for Phenylephrine 1.0% in children 6 to < 12 years

A

,Not recommended for children <12 years except under advice of HCP

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27
Q

What is the recommended dosage for Phenylephrine 1.0% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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28
Q

What is the recommended dosage for Phenylephrine 0.5% in adults

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

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29
Q

What is the recommended dosage for Phenylephrine 0.5% in children 6 to < 12 years

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

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30
Q

What is the recommended dosage for Phenylephrine 0.5% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

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31
Q

What is the recommended dosage for Phenylephrine 0.25% in adults

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

32
Q

What is the recommended dosage for Propylhexedrine 0.4–0.5 mg/800 mL of air in adults

A

,2 inhalations in each nostril not more often than every 2 hours

33
Q

What is the recommended dosage for Propylhexedrine 0.4–0.5 mg/800 mL of air in children 6 to < 12 years

A

,2 inhalations in each nostril not more often than every 2 hours

34
Q

What is the recommended dosage for Propylhexedrine 0.4–0.5 mg/800 mL of air in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

35
Q

What is the recommended dosage for Xylometazoline 0.1% in adults

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours

36
Q

What is the recommended dosage for Xylometazoline 0.1% in children 6 to < 12 years

A

,Not recommended for children <12 years except under advice of HCP

37
Q

What is the recommended dosage for Xylometazoline 0.1% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

38
Q

What is the recommended dosage for Xylometazoline 0.05% in adults

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours

39
Q

What is the recommended dosage for Xylometazoline 0.05% in children 6 to < 12 years

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours (maximum: 3 doses/ 24 hours)

40
Q

What is the recommended dosage for Xylometazoline 0.05% in children 2 to < 6 years

A

,Not recommended for children <6 years except under advice of HCP

41
Q

What is the dosage for adults and children ≥ 12 years of Ephedrine 0.5%

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

42
Q

What is the dosage for children 6 to < 12 years of Ephedrine 0.5%

A

,1–2 drops/sprays in each nostril not more often than every 4 hours

43
Q

What is the dosage for children 2 to < 6 years of Ephedrine 0.5%

A

,Not recommended for children <6 years except under advice of HCP

44
Q

What is the dosage for adults of Levmetamfetamine 0.04–0.15 mg/800 mL of air

A

,2 inhalations in each nostril not more often than every 2 hours

45
Q

What is the dosage for children 6 to < 12 years of Levmetamfetamine 0.04–0.15 mg/800 mL of air

A

,1 inhalation in each nostril not more often than every 2 hours

46
Q

What is the dosage for children 2 to < 6 years of Levmetamfetamine 0.04–0.15 mg/800 mL of air

A

,Not recommended for children <6 years except under advice of HCP

47
Q

What is the dosage for adults of Naphazoline 0.05%

A

,1–2 drops/sprays in each nostril not more often than every 6 hours

48
Q

What is the dosage for children 6 to < 12 years of Naphazoline 0.05%

A

,Not recommended for children <12 years except under advice of HCP

49
Q

What is the dosage for children 2 to < 6 years of Naphazoline 0.05%

A

,Not recommended for children <6 years except under advice of HCP

50
Q

What is the dosage for adults and children ≥ 12 years of Oxymetazoline 0.05%

A

,2–3 drops/sprays in each nostril not more often than every 10–12 hours (maximum: 2 doses/ 24 hours)

51
Q

What is the dosage for children 6 to < 12 years of Oxymetazoline 0.05%

A

,2–3 drops/sprays in each nostril not more often than every 10–12 hours (maximum: 2 doses/ 24 hours)

52
Q

What is the dosage for children 2 to < 6 years of Oxymetazoline 0.05%

A

,Not recommended for children <6 years except under advice of HCP

53
Q

What is the dosage for adults of Phenylephrine 1.0%

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

54
Q

What is the dosage for children 6 to < 12 years of Phenylephrine 1.0%

A

,Not recommended for children <12 years except under advice of HCP

55
Q

What is the dosage for children 2 to < 6 years of Phenylephrine 1.0%

A

,Not recommended for children <6 years except under advice of HCP

56
Q

What is the dosage for adults of Phenylephrine 0.5%

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

57
Q

What is the dosage for children 6 to < 12 years of Phenylephrine 0.5%

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

58
Q

What is the dosage for children 2 to < 6 years of Phenylephrine 0.5%

A

,Not recommended for children <6 years except under advice of HCP

59
Q

What is the dosage for adults of Phenylephrine 0.25%

A

,2–3 drops/sprays in each nostril not more often than every 4 hours

60
Q

What is the dosage for adults of Propylhexedrine 0.4–0.5 mg/800 mL of air

A

,2 inhalations in each nostril not more often than every 2 hours

61
Q

What is the dosage for children 6 to < 12 years of Propylhexedrine 0.4–0.5 mg/800 mL of air

A

,2 inhalations in each nostril not more often than every 2 hours

62
Q

What is the dosage for children 2 to < 6 years of Propylhexedrine 0.4–0.5 mg/800 mL of air

A

,Not recommended for children <6 years except under advice of HCP

63
Q

What is the dosage for adults of Xylometazoline 0.1%

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours

64
Q

What is the dosage for children 6 to < 12 years of Xylometazoline 0.1%

A

,Not recommended for children <12 years except under advice of HCP

65
Q

What is the dosage for children 2 to < 6 years of Xylometazoline 0.1%

A

,Not recommended for children <6 years except under advice of HCP

66
Q

What is the dosage for adults of Xylometazoline 0.05%

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours

67
Q

What is the dosage for children 6 to < 12 years of Xylometazoline 0.05%

A

,2–3 drops/sprays in each nostril not more often than every 8–10 hours (maximum: 3 doses/

68
Q

Question,Answer
What are the advantages of nasal sprays as a delivery form?

A

imple to use, cover a large surface area, relatively inexpensive, and have a fast onset of action.

69
Q

What are the disadvantages of nasal sprays as a delivery form?

A

Imprecise dosage, a tendency for the tip to become clogged with repeated use, and a high risk of contamination from aspiration of nasal mucus into the bottle.

70
Q

What are the advantages of metered pump sprays as a delivery form?

A

Deliver a more precise dose.

71
Q

What are the advantages of nasal drops as a delivery form?

A

Preferred for small children.

72
Q

What are the disadvantages of nasal drops as a delivery form?

A

Can be difficult to use, cover a limited surface area, and pass easily into the larynx. A high risk of contamination from touching the dropper to the nasal mucosa during administration is also recognized.

73
Q

What are the advantages of nasal inhalers as a delivery form?

A

Small and convenient to use.

74
Q

What are the disadvantages of nasal inhalers as a delivery form?

A

Require an unobstructed airway and sufficient air flow to distribute the drug to the nasal mucosa. Lose efficacy after 2–3 months due to dissipation of the active ingredien

75
Q

What factors have been shown to be associated with reduced efficacy of topical nasal dosage forms?

A

Presence of nasal polyps, enlarged turbinates, and abnormalities such as septal deviation.