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Step 1 > Corynebacterium diphtheriae > Flashcards

Corynebacterium diphtheriae Flashcards

1
Q

Morphology? (Gram, shape, colonies)

A

Gram + Rod
Coryne = Club-Shaped
Black colonies on cystine-tellurite agar

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2
Q

Exotoxin?

A

Encoded by Beta-prophage

Inhibits protein synthesis via ADP-ribosylation of EF-2

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3
Q

Symptoms?

A 
Pseudomembranous pharyngitis
(not to be confused with pseudomembranous colitis, which was caused by C. difficile)
LAD
Myocarditis
Arrhythmias
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4
Q

Diagnosis

A

Gram + rods w/ metachromatic granules

Positive Elek test for Beta-prophage toxin

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5
Q

The ABCDEFG’s of Diphtheria

A 
ADP-ribosylation
B-prophage
Corynebacterium
Diphtheriae
Elongation
Factor-2
Granules
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