Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Rs Micro > Corynebacterium Diphtheria 🌽🦠 > Flashcards

Corynebacterium Diphtheria 🌽🦠 Flashcards

1
Q

What’s the main characteristics of corynebacterium diphtheria ⁉️

A 
🦠gram + with rods 
🦠non-capsulated
🦠nonspor formation 
🦠pleomorphic
🦠Chinese character 🇨🇳
🦠cluster of parallel rays
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why does the corynebacterium diphtheria has a clubbed end🏒⁉️

A

🔸because of volutin granules ➡️to act as storage place for inorganic polyphosphate ➡️to use it as a food during tough environment 🌚

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why do we have a decline in the corynebacterium diphtheria trend ⁉️

A

Because of vaccine 💉

🔹before vaccinations the children below 12 years old were effected the most
🔹after vaccination 💉 the bacteria shifted into adults because of the incomplete immunity status 🙂➡️due to alcohol 🍷 or immunocompramized😷

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Transmission of diphtheria ⁉️

A

🌚respiratory droplets 💧

🙂indicated skin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Reservoir of diphtheria ⁉️

A

Only human 😛

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Carriers of corynebacterium diphtheria ⁉️

A

🔹nasal carriers ➡️more dangerous due to the amount of shedding

🔹throat carriers ➡️less dangerous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Sources Of infection(يعني كيف العدوة حتىصلني كشخص سليم )⁉️⁉️⁉️

A

🔹carries ➡️95% (nasal carries and throat carrier )
🔹case ➡️5%

لانو الشخص اللي ظاهرة عليه الاعراض سيأخذ التدابير اللازمة ويتعالج على عكس الشخص الحامل للبكتيريا بدون اخد علاج وظهور اعراض 🌚

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Corynebacterium diphtheria toxin ⁉️

A

🔸it’s two subunit toxins (a&b)
🔸it’s expressed after bacteriophage infection
🔸it can produce antitoxins
🔸A➡️catalytic domain
🔸b➡️receptor binding domain &translation domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Types of diphtheria ⁉️

A

🔻pulmonary diphtheria
🔻cutaneous diphtheria
🔻systematic diphtheria ➡️due to toxin absorption 💀💢💢

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What’s the most common type of diphtheria ⁉️

A

🫁respiratory diphtheria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Incubation period 🌚

A

هي الفترة بين حدوث الinfection وبين ظهور الاعراض

➡️3-4 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

We have 3 stages of diphtheria mention them⁉️⁉️

A

🔸faucial diphtheria ➡️in fauces (the cavity between mouth and pharynx )🌚
🔸extension of membrane
🔸bull neck apperance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Faucial stage of diphtheria ⁉️

A

🔸it’s the cavity between the back of the mouth and the pharynx
🔸it starts with diphtheria penetration of skin or mucous membranes
🔸then bacteria 🧫 will start to multiples in order to make exotoxins
🔸production of toxins will lead to edema ,hyperemia,vacslar congestion

➡️that will lead to increase permeability of blood vessels 🩸
➡️epithelial necrosis
➡️local damge

🔸fibrinogen will react with thrombplastin of the necrotic tissue and converted into fibrin (diphtheritic membrane )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What’s the diphtheritic membrane ⁉️

A

🔺it’s made of insoluble fibrin ,bacteria ,macrophages,necrotic tissue
🔺attached tightly to mucosa ➡️if you try to remove it you will cause tissue bleeding 🩸
🔺increase in thickness up to 5-6 days of infection
🔺has a tendency to expand into another organ
🔺detach after 5-10 day
🔺thick ,leathery ,greywhite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Components of pseudo membranes diphtheritic ⁉️

A

🔹bacteria
🔹phagocytes
🔹necrotic epithelium
💢fibrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Manifestations of corynebacterium diphtheria ⁉️➡️respiratory diphtheria

A 
🔹low fever 🥵 
🔹headache 🙂
🔹weakness 
🔹voice changes 
🔹dysphagia 
🔹sore throat
17
Q

Stage 2 of respiratory diphtheria ⁉️

A 
🔺extension of pseudomembrane 
➡️in sever cases only 
➡️extended to larynx &bronchial airways 
➡️fatal airway obstruction 
➡️tracheotomy
18
Q

What’s stage 3 in the corynebacterium diphtheria ⁉️

A 
➡️bull neck appearance 
🔹massive tonsils swelling 
🔹lymphadenopathy 
🔹edema in submandibular and paratraheal area 
➡️manifestations 
🔸thick speach 
🔸foul breath 
🔸stridor breathing 😮‍💨 صرير
19
Q

The diphtheritic psudeomembranous is gone after ⁉️🙂

A

🔻5-10 days

20
Q

What’s the diphtheritic pharyngitis and streptococcal pharyngitis ⁉️

A

🔹diphtheria pharyngitis
➡️well demarcated
➡️grey white
➡️tightly attached

🧫streptococcal pharyngitis
➡️exidative lesion (less demarcated)
➡️less attached

21
Q

Volutin granules ⁉️🙂

A

A structure found in corynebacterium diphtheria act as a storage place for inorganic polyphospate ➡️to use it when the environment is tough 💀

22
Q

Systematic diphtheria effect 4 places mention them ⁉️

A

🔺adrenal gland
🔺Nervous system
🔺cardio
🔺kidney

23
Q

When does the systematic diphtheria happened ⁉️

A 
When the diphtheria toxin invaded 
🔸subcutaneous tissue 
🔸lymph nodes 
🔸blood stream 
➡️and then to the target  cell 🎯
24
Q

Diphtheria myocarditis ⁉️

A

🩸appears after 2-3 week of respiratory diphtheria

🩸heart weakness,enlargement.arrhythmia and ➡️hf

25
Q

Diphtheria effect on adrenal glands ⁉️

A

🩸hemorrhage

🩸necrosis

26
Q

Diphtheria effect on kidney ⁉️

A

🔻nephrosis➡️disease in kidney tubules 💀

27
Q

Diphtheria effect on nervous system ⁉️

A

🔸apper in the late course of disease
🔸non inflammatory demyelination disorder
🔸paralysis of ➡️selective muscle,oculomotor muscle ,soft palate
🔸usually reversible not serous until diaphragm is involved 🫁💀

28
Q

Recovery time for systematic diphtheria ⁉️

A

4,5 weeks to 6 months 🙂😮‍💨

29
Q

Chronic carriers could shed organism for ⁉️

A

6 month 🙂

30
Q

Without antibiotics treatment the organism presist for

A

🔹2-4 weeks

31
Q

Treatment for corynebacterium diphtheria 💉⁉️

A

🔺antidiphteratic serum ADS ➡️to neutralize the toxin
🔺maintenance an open airways
🔺antimicrbal therapy
➡️penicillin and erythromycin 💉

32
Q

When we could say that the patient is fully treated ⁉️

A

Two negative test ➡️24 hour apart

33
Q

Protection titer🔺

A

When the antitoxin titer is more than 0.1 units/ml

34
Q

Diphtheria vaccine 💉⁉️

A

🔹single vaccine ➡️for adults (toxoid)

🔹combined vaccine

Rs Micro (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions