Corticosteroids

Question 1

Hydrocortisone (cortisol)

Answer 1

Short DOA

adrenocortical deficiency tx

Question 2

Cortisone

Answer 2

Short DOA

cheap, inactive until converted to hydrocortisone

Question 3

Prednisone

Answer 3

Intermediate DOA

Inactive until converted to prednisolone

Question 4

Methylprednisone

Answer 4

Intermediate DOA

Anti inflammatory and immunosuppressive

Question 5

Triamcinolone

Answer 5

Intermediate DOA

More toxic than other corticosteroids

Question 6

Dexamethasone

Answer 6

Long DOA
anti inflammatory and immunosuppressive
used for suppression of adrenocorticotrophic hormone

Question 7

Betamethasone

Answer 7

Long DOA

antiinflammatory and imunosuppressive

Question 8

Fludrocortisone

Answer 8

**Mineralcorticoid
short DOA
Drug of choice for mineralcorticoid effects

Question 9

Amino Glutethimide

Answer 9

Inhibits corticosteroid synthesis
aromatase inhibitor
inhibits conversion of cholesterol to pregnenolone
used in treatment of malignancies of adrenal cortex

Question 10

Ketoconazole

Answer 10

Inhibits corticosteroid synthesis
Strongly inhibits gonadal and adrenal steroid hormone synthesis
used to treat Cushings syndrome

Question 11

Metyrapone

Answer 11

Oral diagnostic agent
inhibits corticosteroid synthesis
Inhibits steroidgenesis 
used to evaluate hypothalamic-pituitary ACTH function
off label treatment for Cushings

Question 12

Prednisolone

Answer 12

Intermediate acting

Drug of choice for immunosuppression and anti inflammatory effects