Corticosteriods Flashcards
what stimulates the release of ACTH from ant pituitary
what does ACTH do
CRH (corticotropin releasing hormone)
ACTH goes to adrenal gland and stimulates aldosterone and cortisol
mineralcorticoids
glucocrticoids
mineral= aldosterone
gluco= cortisol
what is the negative feedback to the production of cortisol and aldosterone
cortisol turns off production in pituitary and hypothalamus
what else triggers ACTH in ant pituitary
renin??
what do glucocorticoids do
cortisol
- stimulate glucose synthesis in liver= increase blood sugar
- decrease protein syn and stimulate catabolism of cellualr proteins
- mobilizes fat
- increases RBC and WBC
- promotes renal excretion of Ca (osteoporsis = risk )
- anti inflamm properties
if in excess= cushings
why do we use glucocorticoids
want the anti inflammatory effects
what do mineralocorticoids do
stimulate absorption of Na in ECF result in reabsorb water
waste K
retain na/waste K
where are glucocorticoid receptors
all over body
steriod crosses cell membrane via passive diffusion binds intracellular receptor
enters nucleus cause increase production of MRNA
how well are glucocorticoids aborbed
rapid and completely absorbed
oral=IV
what are the different forms of glucocorticoids
topical (Cream, ointment, lotion, spray)
injectin (IV, IM)
enemas (for local effect)
what are the drugs within the glucocorticoid class
prednisone
methylprednisolone
also dexamethasone
prednisone
most common prescribed glucocorticoid steriod
it is a pro drug
liver turns into active which is prednisolone
what is the standard steriod all other glucocorticoids are compared to
cortisol= 1
the 1 defines its anti inflamm potency
which of the following are stronger acting glucocorticoids (aka more potent anti inflamm- what is important to not about them?)
fludrocortisone prednisone prenisolone 6a-methylprenisolone triamcinolone dexamethasone
dexamethasone= most potent anti inflamm- zero Na retaining potency
6a and triamcinolone also stronger
the more potent anti inflamm= the less Na retaining potency
the stronger the anti inflamm= the longer the duration of action
which of the following glucocorticoids is used in cardiology for people with syncope and why
fludrocortisone prednisone prenisolone 6a-methylprenisolone triamcinolone dexamethasone
fludrocortisone
not used for anti inflamm at all
has the highest Na retaining potency
helps keep BP up by retaining more Na - stops fainting
