Corneal Immunology (M2)

Question 1

Where do corneal dendritic cells come from?

Answer 1

1. myeloid (Bone-marrow)

2. lymphoid lineages (lymph nodes, thymus, tonsil, spleen)

Question 2

Where are corneal dendritic cells more numerous?

Answer 2

More numerous peripherally than centrally

Question 3

When do T cells interact with dendritic cells?

Answer 3

Once “mature” and have MHC II

Question 4

Where are macrophages located in the cornea?

Answer 4

basal stroma

Question 5

Where are PMN’s from that are in the cornea (and how long does it takes for these to be present)?

Answer 5

1. limbal blood vessels (within 12 hours)

2. lacrimal gland and are present in tears (within 6 hours)

Question 6

What does lactoferrin and lipocalin do in the cornea?

Answer 6

makes iron unavailable for bacteria

Question 7

What immune mechanism binds to surface pathogens to help prevent access to ocular surface?

Answer 7

IgA + secretory component

Question 8

What immune mechanism binds Gram positive bacteria and kills cell via lipolytic enzymatic activity?

Answer 8

Secreted PhospholipaseA2 (sPLA2)