copy 4 Flashcards
1
Q
State the effect on ADH
A
2
Q
What is the defintion of the set point regarding ADH release?
A
Below the osmolality set point virtually no ADH is released
3
Q
What is the average set point in healthy adults?
A
it varies from 275 to 290 mOsm/kg H 2 O (average, ≈280 to 285 mOsm/kg H 2 O)
4
Q
What does pregnancy do to the set point?
A
Decreases it
5
Q
How do V2 receptors play a role in regulation of water reabsorption?
A
When ADH binds to V2 receptors intracellular levels of cAMP increases
This increase results in the activation of Protein Kinase A
The activation of PKA causes AQP2 channels to be inserted into the external membrane of the cell and it also increases the production of AQP2
This in turn causes increased reaborption of water
