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Question 1

What is used to convert T4 to T3 in tissues with high blood flow?

Answer 1

type 1
deiodinase

Question 2

What is used to convert T4 to T3 in the brain?

Answer 2

type 2 deiodinase

Question 3

What is the function of type 3 deiodniase?

Answer 3

D3 is a high-affinity inner ring deiodinase that converts T4 to the inactive rT3.

Question 4

How does T3 induce its direct affects on the CV system?

Answer 4

Direct inotropic effects result from
increased α-myosin heavy chain expression and inhibition of the plasma membrane Na + /Ca 2 + exchanger (NCX).

Question 5

What are the affects of T3 on SERCA2 and phospholamban

Answer 5

Sarcoplasmic reticulum (SR) Ca 2+ ATPase (SERCA2) is increased by T3 and Phospholamban (PLB) is
decreased.

Question 6

There is extra information in the slides but it is very logical, revising it quickly is advised

Question 7

What is graves disease?

Answer 7

Autoimmune disorder that causes hyperthyroidisim

Antibodies activate the TSH receptor leading to hyperthyroidism