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Question 1

What do parafollicular cells/C cells produce?

Answer 1

Calcitonin

Question 2

How is Iodide transported into the thyroid gland?

Answer 2

Iodide is actively transported into the
gland by a sodium-iodide symporter (NIS)

Question 3

What inhibits and activates NIS gene?

Answer 3

Expression of the NIS gene is inhibited
by iodide and stimulated by TSH

Question 4

What is the channel that iodide uses to go into the lumen called?

Answer 4

pendrin

Question 5

What oxidizes Iodide?

Answer 5

Thyroid peroxidase

Question 6

What is the incorporation of iodide into thyroglobulin called?

Answer 6

It is called iodination or organfication

Question 7

What does a single, double, and addition iodination called?

Answer 7

Adding a single iodide tyrosine residue on thyroglobluin will form Monoiodotyrosine (MIT)

Adding another iodide molecule to the same tyrosine residue will form Diiodotyrosine (DIT)

Coupling two DIT molecules will form Tetraiodothyronine (T4)

Coupling a DIT molecule and an MIT molecule will form Triiodothyronine (T3)

This whole process is done by thyroid peroxidase