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Question 1

What are the precursors of adrenal androgens and how are they converted to androgens?

Answer 1

17-hydroxypregnenolone and17-hydroxyprogesterone

converted: to androgens by removal of the C20,21 side chain.

Question 2

Why does the zona glomerulosa not produce glucocorticoids?

Answer 2

The zona glomerulosa does not produce glucocorticoids for two reasons:

(1) Corticosterone, a glucocorticoid, is converted to aldosterone because this zone contains aldosterone synthase.

(2) The zona glomerulosa lacks 17α -hydroxylase and therefore
is unable to produce cortisol from progesterone

Question 3

What are two steroids with mineralocorticoid activity other than aldosterone?

Answer 3

11-deoxycorticosterone, and corticosterone

Question 4

What happens to mineralocorticoid production if the pathway is blocked below the level of 11-deoxycorticosterone?

Answer 4

Minerlocorticoids will still be produced

Question 5

What are two enzymes that are below the level of 11-deoxycorticosterone?

Answer 5

aldosterone synthase and 11b-hydroxylase

Question 6

What happens to mineralocorticoid production if the pathway is blocked above the level of 11-deoxycorticosterone?

Answer 6

then no mineralocorticoids
will be produced.

Question 7

What is an enzyme that is above the level of 11-deoxycorticosterone?

Answer 7

21β -hydroxylase