Copper

Question 1

Biochem function

Answer 1

component of Cu Metalloenzymes. acting as oxidases to reduce molecular oxygen

Question 2

lysyl oxidase

Answer 2

crosslinking collagen + elastin

Question 3

Cu/Zn SOD

Answer 3

defense against oxidative damage

Question 4

Dopamine

Answer 4

(monooxygenase). uses Vit C, Cu, O2 to convert to norepinephrine

Question 5

monoamine oxidase (MAO)

Answer 5

serotonin degradation, metabolism of catecholamines.

MAO inhibitors are antidepressants

Question 6

Ferroxidases

Answer 6

oxidizes iron. Cu enzymes in plasma and function in Fe2+ oxidation needed to bind iron to transferrin

Question 7

Ceruloplasmin

Answer 7

carries Cu in plasma

Question 8

Cu deficiency

Answer 8

usually secondary to intestinal resection,

inc Zinc intake, or infants fed cow’s milk

Question 9

Cu Absorption– transport proteins

Answer 9

Cu transporter 1 (CTR1)
ATPase7A
Metallothionine

(-) absorption: Zn, Vit C, fructose

Question 10

Assessment

Answer 10

plasma Cu, serum ceruloplasmin, RBC SOD activity, platelet Cu

Question 11

physiologic functions

Answer 11

connective tissue formation, CNS, cardiac function, cholesterol metabolism, immune competence

Question 12

acrodermatitis enteropathica

Answer 12

autosomal recessive, low blood Zn. (MNT- Zn)

Sx: skin inflammation, diarrhea, balding, dec wound healing, immune deficiency

Question 13

Menke’s disease

Answer 13

recessive x linked mutation in ATP7B, Cu transporting ATPase
inc Cu in liver (–> cirrhosis, liver failure), brain (–> movement disorders, seizures, personality changes, depression, psychosis, kayser fleischer rings