COPD 2 Flashcards
What is the formulation of pMDI?
-Drugs suspended or dissolved in propellant (with surfactant and cosolvent)
What is the metering system if pMDI?
-Metering valve and reservoir
What are advantages of pMDI?c
- Portable and compact
- Multidose device
- Relatively inexpensive
- Cannot contaminants contents
- Available for most inhaled medication
- Dose indicator (new generation devices)
What are the disadvantages of pMDI?
- Contains propellants
- Not breath actuated
- Many patients cannot use it correctly
- High oropharyngeal deposition
What are the advantages of pMDI and spacer?
- Low dependence on inspiratory flow rate
- Easier to coordinate
- Large drug disease delivered more conveniently
- Less oropharyngeal deposition
- Low dependance on inspiratory flow rate
- Higher lung deposition than a pMDI
What are the disadvantages of of pMDI and spacer?
- less portable than a pMDI
- Plastic spacers may acquire static charge
- Additional cost to a pMDI
What is there formulation of DPI?
Drug blend in lactose, drug alone, drug/excipient particles
What is the formulation of SMI?
Aqueous solution or suspension
What is the metering system of DPI?
-Capsules, blisters, multi dose blister packs, reservoirs
What is the metering system of SMI (Respimat) ?
-A spring loaded system provides the energy required to force aqueous solution from a reservoir through the “uniblock” to produce the soft mist
What are the advantages of DPI?
- Portable and compact
- Breath actuated (no coordination needed)
- Does not contain propellants
- Dose indicator (new generation devices)
- Locking mechanisms when empty (new generation devices)
What are the disadvantages of DPI?
- Requires a minimum inspiratory flow
- May not be appropriate for emergency situation
- Many patients cannot use it correctly
- Most types are moisture sensitive
What are the advantages of the SMI?
- Portable and compact
- Multidose device
- Low dependence on inspiratory flow rate (slow moving aerosol)
- High fine particle fraction
- High lung deposition
- Does not contain propellants
- Dose indicator
- Locking mechanism when empty
What are the disadvantages of SMI?
- Not breath actuated
What are spacers?
- Spacers (or holding chamber) are large empty devices (or tubes) that are usually made out of plastic and they help you get the best from your asthma medicine of you use a metered dose inhaler (MDI)
- Using a spacers makes it easier to get the right amount of medicine straight to your lungs, where it is needed
- Using a spacer can also reduce the risk of side effects from your medicine