copd Flashcards
COPD definition
Presence of airflow obstruction due to chronic bronchitis or emphysema
- Obstruction is generally progressive -> PREVENTABLE AND TREATABLE DS
-+/- airway hyper-reactivity
-+/- PARTIALLY reversible
-Most patients with COPD have features of both emphysema and chronic bronchitis
Cause of COPD:
-significant exposure to noxious particles or gases
COPD sx and risk factors
Symptoms:
- MC: Dyspnea, cough, +/- sputum
Risk factors:
- TOBACCO Smoking**
- Occupation Dusts
- Air pollution
- Hereditary factors (deficiency of α1-antiprotease = emphysema)
chronic bronchitis vs emphysema dx
Chronic bronchitis:
-Clinical diagnosis*
-Daily* productive cough for 3 months or more for at least 2 consecutive years*
–
Emphysema:
-Pathologic diagnosis*
-Abnormal permanent enlargement of air spaces distal to the terminal bronchiole, with destruction of their walls and without obvious fibrosis
emphysema pathogenesis
-excessive LYSIS OF ELASTIN (structural proteins) by elastase from lung neutrophils, macrophages, and mononuclear cells
Outcome:
- permanent enlargement of airway spaces
- Destruction of alveoli
- destruction of connective tissue and pulmonary capillaries
-Airways floppy (increased compliance)
-Air flow obstruction
It can progress to….
-V/Q Mismatch
-Cor pulmonale: END STAGE COPD
Excessive elastase activity: Conditions like cigarette smoking, air pollution, and certain infections can activate neutrophils, macrophages, and mononuclear cells in the lungs to release higher amounts of elastase enzymes.
-V/Q Mismatch emphysema vs bronchitis
Emphysema: PERFUSION ISSUE (PE)
- Dead space ventilation
- ventilating areas not perfused due to destruction of capillaries
- ventilated well but not perfused
Chronic bronchitis: VENTILLATION ISSUE (CV)
- Capillaries intact, but not ventilated due to mucus plugs blocking air
- perfused well but not ventilated
Types of emphysema
Centrilobular-MC**
Panlobular- a1 antitrypsan deficency
Paraseptal
Irregular
air trapping in COPD (mostly emphysema)
COPD:
-loss of alveolar attachments and thickened inflammated airway
-loss of elasticity (emphysema)
outcome:
-airway collapses on expiration -> AIR TRAPPING bc inefficient breathing
-a lot of air trapping = SOB
–
DLCO pattern emphysema vs chronic bronchitis
Emphysema:
-alveoli are being destroyed, though they are increasing in size, the surface area ↓↓↓ = ↓ DLCO
Chronic bronchitis:
- NORMAL
- main problem is mucus and inflammation/narrowing of airway -> alveoli are functional
chronic bronchitis
-Hypertrophy bronchial mucous glands (plugging)
-Goblet cells increase in number
-Damaged cilia
-Bronchial mucosa inflammation
-Bronchial smooth muscle hyper-reactivity -> Bronchospasm
-Increase in MUCOUS production:
–
-Air flow obstruction
-V/Q mismatch
-Cor Pulmonale
presentation/symptoms of COPD 3 typical presenations
1: Few complaints, but extremely sedentary lifestyle
2: Chronic respiratory symptoms:
-Dyspnea on exertion, cough
3: Acute exacerbation
- Wheezing, PURULENT cough, dyspnea
physical exam: early and mod-severe ds
Early disease:
-Nl or prolonged expiration
-Wheezes
Moderate-severe:
Hyperinflation & air trapping
Decreased breath sounds: Wheezes, rhonchi, crackles
Increased AP diameter
end stage COPD
Significant trouble with expiration = need to reposition to exhale
- May be hypoxic = cyanotic
- May have light HF or HTN
Hoover’s Sign: Paradoxical retraction of lower interspaces during inspiration - sign of hyperinflation (emphysema)
Cor Pulmonale: Enlarged, tender liver +/- neck vein distention
type A pink puffer - emphysema sx
-Often presenting after age 50
Sx:
-DYSPNEA often severe*
-Cough = rare scant clear, mucoid sputum
-Present as thin (wt loss)
- Using accessory muscles for inspiration
-Chest is QUIET -> no congestion in lungs
-NO peripheral edema
- mostly normal labs because of compensatory mechanism -> pursed lips
Pink = “normal skin color”
Puffer = “pursed lips”
–
Chest xray pink puffer
-Hyperinflation, FLAT diaphragms
-Vascular markings DECREASE
-Parenchymal BULLAE*
Sx:
-DYSPNEA severe
- Using accessory muscles for inspiration
-Chest is QUIET -> no congestion in lungs
-NO peripheral edema
Chest xray blue bloater
INCREASED interstitial markings *
sx:
- Chest is noisy with rhonchi, wheezes