COPD

Question 1

COPD is progressive. Examples include chronic bronchitis and..?

Answer 1

Emphysema

Question 2

Main cause of COPD?

Answer 2

Smoking, exposure to smoke, etc

Question 3

True or false. The smooth muscle in the airway of COPD patient is thicker than asthmatic

Answer 3

False. COPD doesn’t have as much smooth muscle proliferation

Question 4

Which cells are involved in the tissue damage of COPD?

Answer 4

Macrophages and neutrophils and T1 helper cells

Question 5

Tissue damage reduces the elastic recoil of the lungs. What else makes it difficult for COPD patients to breath?

Answer 5

Excessive mucus production, narrowed bronchioles and alveoli destruction

Question 6

Are neutrophils raised in COPD or asthma or both?

Answer 6

COPD only

Question 7

True or false. COPD patients have normal levels of mast cell, dendritic cells and eosinophils.

Answer 7

True. All are raised in asthma

Question 8

Epithelial cells in COPD recruit fibroblasts which cause what?

Answer 8

Fibrosis / scarring

Question 9

ADRs of anticholinergics?

Answer 9

Anti-SLUDGE (dry)

Question 10

Name 2 LAMAs

Answer 10

Tiotropium and glycopyrronium

Question 11

Action of LAMAs in COPD?

Answer 11

Decrease the ACh mediated muscle contraction + reduce vagal tone

Question 12

Which LAMA is more selective for M3?

Answer 12

Tiotropium