Conversion of pyruvate to Acetyl CoA

Question 1

What does pyruvate use to turn into a two carbon molecule

Answer 1

Pyruvate uses pyruvate dehydrogenase to convert into Acetyl CoA

Question 2

What enzymes does pyruvate dehydrogenase consist of

Answer 2

Pyruvate, CoA and NAD+

Question 3

What are the three steps of converting pyruvate into Acetyl CoA

Answer 3

Decarboxylation, oxidation and transfer of acetyl group to CoA

Question 4

Detail the steps of converting pyruvate into acetyl coa

Answer 4

Decarboxylation: Pyruvate combines with TPP and is decarboxylated to result in hydroxyethyl TPP

Oxidation: The hydroxyethyl group is oxidised to an acetyl group and is transferred to lipoamide

Formation of Acetyl CoA: The acetyl group is transferred from acetyl lipoamide to CoA to form Acetyl CoA