Control Of Blood Water Potentail Flashcards
Whta is osmoregution
Control of blood water potential bias homeostatic mechanisms
where does osmoregulation kidney
nephrons
describe the nephron structure
long tubules surrounded by capillaries
renal capsule with glomerulus - at the start of the nephron: cup shaped, surrounds glomerulus
proximal convoluted tubule - series of loops surrounded by capillaries walls, walls made up of epithelial cells with microvilli
loop of Henle - hairpin loop extends from cortex into medulla
distal convoluted tubule - similar to PCT but fewer capillaries
collecting ducts -DCT from several nephrons empty into collecting duct
function of the nephron
filter the blood to remove waste and selectively reabsorb useful substances back into the blood
what does urine contain
water
dissolved slats
urea
other small substances
what does urine not contain
protein and bloods = protein are too large to be filtered out of the blood
glucose = all glucose is absorbed at selective reabsorption in the PCT
how does filtering and reabsorption occur
stage 1: ultrafiltration
- occurs due high hydrostatic pressure, water and small molecules are forced out of the glomerulus capillaries into the renal capsule
stage2: selective reabsorption
- occurs in the proximal convoluted tubule
- 85% filtrate gets reabsorbed into blood
stage 3&4: the loop of Henle
- maintains a sodium ion gradient so water can be reabsorbed by the blood
stage 5&6
- water moves out of the distal convoluted tubule and collecting duct to return back to the blood
- the collecting duct then carries the remaining liquid(urine) to the ureter
what is ultrafiltration.
- blood enter kidney via the renal artery at high pressure
- renal artery divides into the afferent arteriole, then the glomerulus = cause high hydrostatic pressure of the blood
- water and smaller molecules such eg glucose and mineral ions are forced out of the glomerulus down a pressure gradient into the bowman’s capsule
- pressure gradient aided by the efferent article leaving the glomerulus being narrower than the afferent arteriole
- proteins left behind in blood as they are too large
describe selective reabsorption
- glucose re absorbed by co transport from epithelial cells of the proximal convoluted tube to blood capillaries
- carried out by active transporting Na+ ions creating low Na+ conc in epithelial cells
- Na+ moved from the PCT lumen by facilitated diffusion, which also brings in glucose
adaptions of proximal convoluted tubule
microvilli - large SA for reabsorption
lots of mitochondria - provide ATP for active transport
how is sodium ion gradient maintained by the loop of Henle
- mitochondria in the walls of the cells provide energy to actively transport sodium ions out of the ascending limb out of the loop of henle
- accumalauition of Na+ outside of the nephron in the medulla lower wp
- water diffuses out by osmosis into the interstitial space and then the blood capillaries, water reabsorbed into the blood
- at the base of the ascending limb some Na + are transported out by diffusion
reabsorption of water at the DCT and collecting duct
- water moves out the DCT and collecting duct by osmosis
- collect duct runs parallel to loop of Henle so ion conc increases as you moe down into medulla
Process of osmoregulation