Control and Coordination Flashcards
Outline how the endocrine system works:
- hormonal
- chemical messengers
- ductless glands
- transmitted in the bloodstream
- effectors are target cells/organs
- hormone will bind to receptors on cell membranes
- slow response
- response is widespread and long lasting
Outline how the nervous system works:
- impulses/action potentials
- travel along neurones
- receptors and sensory neurones
- effectors (muscle/gland) and motor neurones
- travel along synapses
- speed of transmission is very fast
- response is not widespread and is short-lived
Describe the structure of a myelinated sensory neurone
- nucleus in cell body
- long dendron
- shorter axon
- many mitochondria in cell body
- many RER in cell body
- synaptic knobs
- terminal dendrites
myelin
- Schwann cells
- nodes of Ranvier
Describe the structure of a motor neurone:
- nucleus in cell body
- cell body is in brain/spinal cord
- short dendrites
- long axon
- many mitochondria/RER/golgi in cell body
- many mitochondria at synaptic knob
- synaptic vesicles
myelin
- Schwann cells
- nucleus in Schwann cell
- nodes of Ranvier
Describe the structure of a relay neurone
- found in the CNS
- un-myelinated
- cell body at end of neurone
- many mitochondria in cell body
- RER in cell body
- nucleus in cell body
- terminal dendrites
How is an action potential transmitted along a sensory neurone?
- Sodium channels open
- Na+ enter cells
- inside of axon becomes less negative and the membrane becomes depolarised
repolarisation
- sodium channels close
- potassium channels open
- K+ moves out of cell
- inside of axon becomes negative/ membrane repolarised
- myelin sheath insulates axon
- action potential occurs at nodes only
- saltatory conduction
- one-way transmission
What is an action potential?
- a change in the potential difference from -70mV to +30mV across membrane
- due to inward movement of Na+ ions
What is a resting potential?
- when a neurone is not transmitting an action potential
- normally -70mV inside
How is a resting potential maintained?
-
Na-K pumps in cell surface membrane
- use ATP to pump 3Na+ out, and 2K+ in - Presence of many organic anions inside axon
- K+ ions attracted to anions, prevent loss of K+ -
Impermeability of axon membrane to ions
- ions cannot escape out -
Closure of voltage-gated channel proteins
- Na+ and K+ cannot diffuse through membrane
What is depolarization?
- influx of Na+ ions
- results in inside of axon becoming positively charged
What is repolarization?
- when potential difference returns back to normal across a cell surface membrane (-70mV)
- Na+ channels close
- K+ channels open
- K+ diffuse out of axon
How is the speed of conduction of impulses controlled?
- myelin sheath speeds up transmission
- insulates axon
- myelin impermeable to Na+/K+
- depolarization only at nodes of Ranvier
- action potentials “jump” from node to node
- saltatory conduction
- axons with large diameter
- larger SA, more depolarization
- reduce resistance
Describe how a nerve impulse crosses a cholinergic synapse:
- action potential reaches presynaptic membrane
- depolarization of membrane results in Ca2+ channels opening
- Ca2+ floods into presynaptic knob
- this causes vesicles of acetylcholine (Ach)
- to move towards and fuse with presynaptic membrane
- Ach released into synaptic cleft
- Ach diffuses across cleft
- Ach binds to cholinergic receptors on postsynaptic membrane
- proteins change shape causing sodium channels to open
- Na+ diffuses into postsynaptic neurone
- postsynaptic membrane depolarized
- acetylcholinesterase breaks down Ach
Explain the role of a synapse:
- ensure one-way transmission
- receptors only in postsynaptic membrane
- vesicles in presynaptic neurone
- wide range of responses
- due to interconnection of many nerve pathways
Describe the structure of a striated muscle:
- made of muscle fibres
- cell surface membrane of muscle fibre is called sarcolemma
- cytoplasm of muscle cell is called the sarcoplasm
- contains sarcoplasmic reticulum
- sarcolemma has deep infoldings called T-tubules that send impulses to the SR
- myofibrils which are cylindrical bundles of actin and myosin