contraindications Flashcards
Contraindications
The following are contraindications for different classes of oral hypoglycemic drugs.
Metformin: Hypersensitivity to the drug, severe renal dysfunction (eGFR less than 30 mL/minute/1.73 m2), and metabolic acidosis, including diabetic ketoacidosis.
Sulfonylureas: Hypersensitivity to the drug or sulfonamide derivatives, type 1 diabetes mellitus, and diabetic ketoacidosis.
Pioglitazone: Hypersensitivity to the drug, New York Heart Association Class III or IV heart failure, serious hepatic impairment, bladder cancer, history of macroscopic hematuria, and pregnancy.
https://www.ncbi.nlm.nih.gov/books/NBK482386/
Alpha-glucosidase inhibitors: Hypersensitivity to acarbose, diabetic ketoacidosis, cirrhosis, inflammatory bowel disease, ulcers of the intestine, partial intestinal obstruction, digestive and absorptive issues
SGLT 2 inhibitors: History of serious hypersensitivity to the drug, end-stage renal disease (ESRD), and patients on dialysis.
DPP-4 inhibitors: Dose adjustment of saxagliptin in needed for eGFR less than 45 mL/min/1.73 m^2 with the dose of 2.5 mg once daily. For Sitagliptin, a low dose of 25 mg daily is given in patients with a creatinine clearance of less than 30 ml/min/1.73 m^2 and is contraindicated in patients with hemodialysis or peritoneal dialysis. Linagliptin does not need any dose adjustment.
Cycloset: Allergy to the drug, breastfeeding, and syncopal migraine
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